Multiphasic Continuous-Flow Reactors for Handling Gaseous Reagents in Organic Synthesis: Enhancing Efficiency and Safety in Chemical Processes

被引：24

作者：

Laporte, Annechien A. H. ^{[1
]}

Masson, Tom M. ^{[1
]}

Zondag, Stefan D. A. ^{[1
]}

Noel, Timothy ^{[1
]}

机构：

[1] Univ Amsterdam, Vant Hoff Inst Mol Sci HIMS, Flow Chem Grp, Sci Pk 904, NL-1098 XH Amsterdam, Netherlands

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2024年 / 63卷 / 11期

基金：

欧洲研究理事会;

关键词：

Flow Chemistry; Gases; Multiphase Reactions; Reactor; Synthetic Methodology; FALLING FILM MICROREACTOR; STIRRED-TANK REACTOR; LIQUID MASS-TRANSFER; STEAM REFORMING MICROREACTOR; VORTEX FLUIDIC DEVICE; SCALE-UP; HETEROGENEOUS CATALYSTS; SELECTIVE HYDROGENATION; PROCESS INTENSIFICATION; SOLID MICROREACTOR;

D O I：

10.1002/anie.202316108

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The use of reactive gaseous reagents for the production of active pharmaceutical ingredients (APIs) remains a scientific challenge due to safety and efficiency limitations. The implementation of continuous-flow reactors has resulted in rapid development of gas-handling technology because of several advantages such as increased interfacial area, improved mass- and heat transfer, and seamless scale-up. This technology enables shorter and more atom-economic synthesis routes for the production of pharmaceutical compounds. Herein, we provide an overview of literature from 2016 onwards in the development of gas-handling continuous-flow technology as well as the use of gases in functionalization of APIs. Using highly reactive gases is appealing for efficient organic synthesis but leads to inherent safety and processing limitations. Embracing continuous-flow technologies helps mitigating those while improving the performance of the systems. Tailored catalyst incorporation opens doors to novel reaction pathways and process intensification. Optimized mass transfer in multiphasic mixtures is key to its success, especially when solids are present.image

引用

页数：28

共 200 条

[1] Evaluation of gas-liquid mass transfer in gas-induced stirred tank reactor using electrical resistance tomography [J].

Abdullah, Bawadi ;

Adesina, Adesoji A. .

JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 2017, 92 (08) :2123-2133

[2] Comparing Gas-Liquid Segmented and Tube-in-Tube Setups for the Aerobic Dimerization of Desmethoxycarpacine with an Automated Flow Platform [J].

Aka, Ehu Camille ;

Wimmer, Eric ;

Barre, Elvina ;

Cortes-Borda, Daniel ;

Ekou, Tchirioua ;

Ekou, Lynda ;

Rodriguez-Zubiri, Mireia ;

Felpin, Francois-Xavier .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2020, 24 (05) :745-751

[3] Enabling the Scale-Up of a Key Asymmetric Hydrogenation Step in the Synthesis of an API Using Continuous Flow Solid-Supported Catalysis [J].

Amara, Zacharias ;

Poliakoff, Martyn ;

Duque, Ruben ;

Geier, Daniel ;

Francio, Giancarlo ;

Gordon, Charles M. ;

Meadows, Rebecca E. ;

Woodward, Robert ;

Leitner, Walter .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2016, 20 (07) :1321-1327

[4] Performance of a dual helical ribbon impeller in a two-phase (gas-liquid) stirred tank reactor [J].

Amiraftabi, Maryam ;

Khiadani, Mehdi ;

Mohammed, Hussein A. .

CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION, 2020, 148

[5]

[Anonymous], The Continuous Stirred Tank Heater Simulation

[6]

Asano S., 2023, J FLOW CHEM, DOI [10.1007/s41981-023--00295-9, DOI 10.1007/S41981-023--00295-9]

[7] Continuous flow hydrogenations using novel catalytic static mixers inside a tubular reactor [J].

Avril, A. ;

Hornung, C. H. ;

Urban, A. ;

Fraser, D. ;

Horne, M. ;

Veder, J-P ;

Tsanaktsidis, J. ;

Rodopoulos, T. ;

Henry, C. ;

Gunasegaram, D. R. .

REACTION CHEMISTRY & ENGINEERING, 2017, 2 (02) :180-188

[8] Application of different advanced oxidation processes for the removal of chloroacetic acids using a planar falling film reactor [J].

Aziz, Kosar Hikmat Hama .

CHEMOSPHERE, 2019, 228 :377-383

[9] The route from problem to solution in multistep continuous flow synthesis of pharmaceutical compounds [J].

Bana, Peter ;

Orkenyi, Robert ;

Lovei, Klara ;

Lako, Agnes ;

Turos, Gyorgy Istvan ;

Eles, Janos ;

Faigl, Ferenc ;

Greiner, Istvan .

BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 25 (23) :6180-6189

[10] Spatial, temporal and quantitative assessment of catalyst leaching in continuous flow [J].

Barreiro, Elena M. ;

Hao, Zhimian ;

Adrio, Luis A. ;

van Ommen, J. Ruud ;

Hellgardt, Klaus ;

Hii, King Kuok .

CATALYSIS TODAY, 2018, 308 :64-70

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