Successful Allergen-Specific Immunotherapy: Induction of Unresponsiveness by 'Vaccination'

被引：1

作者：

Bachmann, Martin F. ^{[1
,2
,3
]}

Vogel, Monique ^{[1
,2
]}

Speiser, Daniel E. ^{[1
,2
,4
,5
]}

机构：

[1] Univ Bern, Dept Biomed Res DBMR, CH-3008 Bern, Switzerland

[2] Univ Hosp Bern, Dept Rheumatol & Immunol, CH-3010 Bern, Switzerland

[3] Univ Oxford, Jenner Inst, Nuffield Dept Med, Oxford OX1 2JD, England

[4] Lausanne Univ Hosp, Dept Oncol, CH-1066 Lausanne, Switzerland

[5] Univ Lausanne, CH-1066 Lausanne, Switzerland

来源：

VACCINES | 2023年 / 11卷 / 12期

基金：

瑞士国家科学基金会;

关键词：

ANTIBODIES; MECHANISMS; TOLERANCE; IGE;

D O I：

10.3390/vaccines11121852

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The mechanisms of action of allergen-specific immunotherapy (AIT) are often referred to as the induction of 'tolerance'. However, immunological 'tolerance' is defined as an alteration in the function or composition of immune cells. For AIT, this is not always the case, because it can also induce allergen-specific IgG antibodies that block allergic responses. To include all possible mechanisms that may mediate successful AIT, it is advantageous to use the scientific term 'unresponsiveness' instead of 'tolerance'. In praxis, the term 'vaccination' is also appropriate, as AIT medications are specialized vaccines.

引用

页数：4

共 24 条

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