Electrostatics in Antibacterial Resistance: Investigating Active Site Electric Fields as the Basis for Catalysis in TEM β-Lactamases

被引：0

作者：

Schulz, Mirjam ^{[1
]}

机构：

[1] Free Univ Berlin, Berlin, Germany

来源：

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS | 2023年 / 52卷 / SUPPL 1期

关键词：

D O I：

暂无

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

P-154

引用

收藏

页码：S105 / S105

页数：1

相关论文

共 39 条

[31] Mutagenesis and structural analysis reveal the CTX-M β-lactamase active site is optimized for cephalosporin catalysis and drug resistance [J].

Lu, Shuo ;

Montoya, Miranda ;

Hu, Liya ;

Neetu, Neetu ;

Sankaran, Banumathi ;

Prasad, B. V. Venkataram ;

Palzkill, Timothy .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2023, 299 (05)

[32] Functional roles in S-adenosyl-L-methionine binding and catalysis for active site residues of the thiostrepton resistance methyltransferase [J].

Myers, Cullen L. ;

Kuiper, Emily G. ;

Grant, Pei C. ;

Hernandez, Jennifer ;

Conn, Graeme L. ;

Honek, John F. .

FEBS LETTERS, 2015, 589 (21) :3263-3270

[33] Structural and Biochemical Evidence That a TEM-1 β-Lactamase N170G Active Site Mutant Acts via Substrate-assisted Catalysis [J].

Brown, Nicholas G. ;

Shanker, Sreejesh ;

Prasad, B. V. Venkataram ;

Palzkill, Timothy .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (48) :33703-33712

[34] Cold-active antibacterial and antifungal activities and antibiotic resistance of bacteria isolated from an alpine hydrocarbon-contaminated industrial site [J].

Hemala, Lydia ;

Zhang, Dechao ;

Margesin, Rosa .

RESEARCH IN MICROBIOLOGY, 2014, 165 (06) :447-456

[35] Vibrational Stark Effects of Carbonyl Probes Applied to Reinterpret IR and Raman Data for Enzyme Inhibitors in Terms of Electric Fields at the Active Site [J].

Schneider, Samuel H. ;

Boxer, Steven G. .

JOURNAL OF PHYSICAL CHEMISTRY B, 2016, 120 (36) :9672-9684

[36] SITE-DIRECTED MUTAGENESIS AT THE ACTIVE-SITE OF ESCHERICHIA-COLI TEM-1 BETA-LACTAMASE - SUICIDE INHIBITOR-RESISTANT MUTANTS REVEAL THE ROLE OF ARGININE-244 AND METHIONINE-69 IN CATALYSIS [J].

DELAIRE, M ;

LABIA, R ;

SAMAMA, JP ;

MASSON, JM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1992, 267 (29) :20600-20606

[37] Multiple Conformers in Active Site of Human Dihydrofolate Reductase F31R/Q35E Double Mutant Suggest Structural Basis for Methotrexate Resistance [J].

Volpato, Jordan P. ;

Yachnin, Brahm J. ;

Blanchet, Jonathan ;

Guerrero, Vanessa ;

Poulin, Lucie ;

Fossati, Elena ;

Berghuis, Albert M. ;

Pelletier, Joelle N. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (30) :20079-20089

[38] Thermodynamic basis of resistance to HIV-1 protease inhibition:: Calorimetric analysis of the V82F/I84V active site resistant mutant [J].

Todd, MJ ;

Luque, I ;

Velázquez-Campoy, A ;

Freire, E .

BIOCHEMISTRY, 2000, 39 (39) :11876-11883

[39] The molecular basis of the expansive substrate specificity of the antibiotic resistance enzyme aminoglycoside acetyltransferase-6′-aminoglycoside phosphotransferase-2" -: The role of Asp-99 as an active site base important for acetyl transfer [J].

Boehr, DD ;

Jenkins, SI ;

Wright, GD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (15) :12873-12880

← 1 2 3 4 →