Optimization of Vaccine Responses in Solid Organ Transplant Recipients

被引：0

作者：

Miller-Handley, Hilary ^{[1
,2
]}

Huaman, Moises A. ^{[1
]}

机构：

[1] Univ Cincinnati, Dept Internal Med, Div Infect Dis, Cincinnati, OH 45221 USA

[2] Cincinnati Childrens Hosp Med Ctr, Div Infect Dis, Cincinnati, OH USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2023年 / 114卷 / 01期

关键词：

D O I：

10.1002/cpt.2909

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Transplant recipients are at increased risk of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) morbidity and mortality. In this issue, Meziyerh and colleagues(1) reported that higher exposures to mycophenolic acid measured by area under the curve (AUC) correlated with diminished quantitative antibody responses and seroconversion rates to mRNA-based coronavirus disease 2019 (COVID-19) vaccination in kidney transplant recipients. These results provide a compelling rationale for future investigations on the role of mycophenolic acid therapeutic drug monitoring and dose modulation for improving vaccine responses in transplant recipients.

引用

页码：26 / 28

页数：3

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