Plasmon-enhanced luminescence (PEL) is a unique photophysical phenomenon in which the interaction between luminescent moieties and metal nanostructures results in a marked luminescence enhancement. PEL offers several advantages and has been extensively used to design robust biosensing platforms for luminescence-based detection and diagnostics applications, as well as for the development of many efficient bioimaging platforms, enabling high-contrast non-invasive real-time optical imaging of biological tissues, cells, and organelles with high spatial and temporal resolution. This review summarizes recent progress in the development of various PEL-based biosensors and bioimaging platforms for diverse biological and biomedical applications. Specifically, we comprehensively assessed rationally designed PEL-based biosensors that can efficiently detect biomarkers (proteins and nucleic acids) in point-of-care tests, highlighting significant improvements in the sensing perfor-mance upon the integration of PEL. In addition to discussing the merits and demerits of recently developed PEL-based biosensors on substrates or in solutions, we include a brief discussion on integrating PEL-based biosensing platforms into microfluidic devices as a promising multi-responsive detection method. The review also presents comprehensive details about the recent advances in the development of various PEL-based multi-functional (passive targeting, active targeting, and stimuli-responsive) bioimaging probes, highlighting the scope of future improvements in devising robust PEL-based nanosystems to achieve more effective diagnostic and therapeutic insights by enabling imaging-guided therapy.
机构:
MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA
MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USAMIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA
Bardhan, Neelkanth M.
Ghosh, Debadyuti
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机构:
MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA
MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
Univ Texas Austin, Coll Pharm, Div Pharmaceut, Austin, TX 78712 USAMIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA
Ghosh, Debadyuti
Belcher, Angela M.
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机构:
MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA
MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
MIT, Dept Biol Engn, Cambridge, MA 02139 USAMIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA
机构:
MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA
MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USAMIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA
Bardhan, Neelkanth M.
Ghosh, Debadyuti
论文数: 0引用数: 0
h-index: 0
机构:
MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA
MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
Univ Texas Austin, Coll Pharm, Div Pharmaceut, Austin, TX 78712 USAMIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA
Ghosh, Debadyuti
Belcher, Angela M.
论文数: 0引用数: 0
h-index: 0
机构:
MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA
MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
MIT, Dept Biol Engn, Cambridge, MA 02139 USAMIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA