Genetic associations with parental investment from conception to wealth inheritance in six cohorts

被引：6

作者：

Wertz, Jasmin ^{[1
]}

Moffitt, Terrie E. ^{[2
,3
,4
,5
,6
]}

Arseneault, Louise ^{[3
]}

Barnes, J. C. ^{[7
]}

Boivin, Michel ^{[8
]}

Corcoran, David L. ^{[9
]}

Danese, Andrea ^{[3
,10
,11
]}

Hancox, Robert J. ^{[12
]}

Harrington, HonaLee ^{[2
]}

Houts, Renate M. ^{[2
]}

Langevin, Stephanie ^{[2
,8
]}

Liu, Hexuan ^{[7
,13
]}

Poulton, Richie ^{[14
]}

Sugden, Karen ^{[2
,5
]}

Tanksley, Peter T. ^{[15
,16
]}

Williams, Benjamin S. ^{[2
,5
]}

Caspi, Avshalom ^{[2
,3
,4
,5
,6
]}

机构：

[1] Univ Edinburgh, Dept Psychol, Edinburgh, Scotland

[2] Duke Univ, Dept Psychol & Neurosci, Durham, NC USA

[3] Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London, England

[4] Univ Oslo, PROMENTA Res Ctr, Oslo, Norway

[5] Duke Univ, Ctr Genom & Computat Biol, Durham, NC USA

[6] Duke Univ, Dept Psychiat & Behav Sci, Durham, NC USA

[7] Univ Cincinnati, Sch Criminal Justice, Cincinnati, OH USA

[8] Laval Univ, Sch Psychol, Quebec City, PQ, Canada

[9] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Genet, Chapel Hill, NC USA

[10] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Child & Adolescent Psychiat, London, England

[11] South London & Maudsley NHS Fdn Trust, Natl & Specialist CAMHS Clin Trauma Anxiety & Depr, London, England

[12] Univ Otago, Dept Prevent & Social Med, Dunedin, New Zealand

[13] Univ Cincinnati, Inst Interdisciplinary Data Sci, Cincinnati, OH USA

[14] Univ Otago, Dept Psychol, Dunedin Multidisciplinary Hlth & Dev Res Unit, Dunedin, New Zealand

[15] Univ Texas Austin, Dept Psychol, Austin, TX USA

[16] Univ Texas Austin, Populat Res Ctr, Austin, TX USA

来源：

NATURE HUMAN BEHAVIOUR | 2023年 / 7卷 / 08期

基金：

英国医学研究理事会; 英国惠康基金; 英国经济与社会研究理事会;

关键词：

EDUCATIONAL-ATTAINMENT; INEQUALITY; GENOTYPE; METAANALYSIS; ETIOLOGY; NURTURE; TIME;

D O I：

10.1038/s41562-023-01618-5

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Genetic inheritance is not the only way parents' genes may affect children. It is also possible that parents' genes are associated with investments into children's development. We examined evidence for links between parental genetics and parental investments, from the prenatal period through to adulthood, using data from six population-based cohorts in the UK, US and New Zealand, together totalling 36,566 parents. Our findings revealed associations between parental genetics-summarized in a genome-wide polygenic score-and parental behaviour across development, from smoking in pregnancy, breastfeeding in infancy, parenting in childhood and adolescence, to leaving a wealth inheritance to adult children. Effect sizes tended to be small at any given time point, ranging from RR = 1.12 (95% confidence interval (95%CI) 1.09, 1.15) to RR = 0.76 (95%CI 0.72, 0.80) during the prenatal period and infancy; & beta; = 0.07 (95%CI 0.04, 0.11) to & beta; = 0.29 (95%CI 0.27, 0.32) in childhood and adolescence, and RR = 1.04 (95%CI 1.01, 1.06) to RR = 1.11 (95%CI 1.07, 1.15) in adulthood. There was evidence for accumulating effects across development, ranging from & beta; = 0.15 (95%CI 0.11, 0.18) to & beta; = 0.23 (95%CI 0.16, 0.29) depending on cohort. Our findings are consistent with the interpretation that parents pass on advantages to offspring not only via direct genetic transmission or purely environmental paths, but also via genetic associations with parental investment from conception to wealth inheritance. A study in 36,516 parents across six international cohorts reveals that parental genetic effects are associated with the investments that parents make in their offspring, from adopting more healthy behaviours during pregnancy to leaving wealth to adult children.

引用

页码：1388 / +

页数：17

共 60 条

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