Mesenchymal stromal cells and CAR-T cells in regenerative medicine: The homing procedure and their effective parameters

被引：7

作者：

Azar, Hanieh Kolahi ^{[1
,2
]}

Imanpour, Aylar ^{[2
]}

Rezaee, Hanieh ^{[2
,3
]}

Ezzatifar, Fatemeh ^{[2
,4
,5
]}

Zarei-Behjani, Zeinab ^{[2
,6
]}

Rostami, Mohammadreza ^{[7
,8
]}

Azami, Mahmoud ^{[2
,9
]}

Behestizadeh, Nima ^{[2
,9
]}

Rezaei, Nima ^{[10
,11
,12
]}

机构：

[1] Tabriz Univ Med Sci, Dept Pathol, Tabriz, Iran

[2] Universal Sci Educ & Res Network USERN, Regenerat Med Grp REMED, Tehran, Iran

[3] Shahid Beheshti Univ Med Sci, Sch Adv Technol Med, Dept Med Biotechnol, Tehran, Iran

[4] Mazandaran Univ Med Sci, Mol & Cell Biol Res Ctr, Sch Med, Dept Immunol, Sari, Iran

[5] Mazandaran Univ Med Sci, Student Res Comm, Sari, Iran

[6] Shiraz Univ Med Sci, Adv Sch Med Sci & Technol, Dept Tissue Engn & Appl Cell Sci, Shiraz, Iran

[7] Univ Tehran Med Sci, Sch Publ Hlth, Dept Environm Hlth Engn, Div Food Safety & Hyg, Tehran, Iran

[8] Universal Sci Educ & Res Network USERN, Food Sci & Nutr Grp FSAN, Tehran, Iran

[9] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Tissue Engn, Tehran, Iran

[10] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran, Iran

[11] Univ Tehran Med Sci, Res Ctr Immunodeficiencies, Childrens Med Ctr, Tehran, Iran

[12] Universal Sci Educ & Res Network USERN, Network Immun Infect Malignancy & Autoimmun NIIMA, Tehran, Iran

来源：

EUROPEAN JOURNAL OF HAEMATOLOGY | 2024年 / 112卷 / 02期

关键词：

CAR-T cells; cell homing; cell therapy; mesenchymal stromal cells; regenerative medicine; VITRO MIGRATION CAPACITY; STEM-CELLS; BONE-MARROW; IN-VITRO; GENETIC-MODIFICATION; HEMATOPOIETIC STEM; TARGETED DELIVERY; PROGENITOR CELLS; RECEPTOR; EXPRESSION;

D O I：

10.1111/ejh.14014

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mesenchymal stromal cells (MSCs) and chimeric antigen receptor (CAR)-T cells are two core elements in cell therapy procedures. MSCs have significant immunomodulatory effects that alleviate inflammation in the tissue regeneration process, while administration of specific chemokines and adhesive molecules would primarily facilitate CAR-T cell trafficking into solid tumors. Multiple parameters affect cell homing, including the recipient's age, the number of cell passages, proper cell culture, and the delivery method. In addition, several chemokines are involved in the tumor microenvironment, affecting the homing procedure. This review discusses parameters that improve the efficiency of cell homing and significant cell therapy challenges. Emerging comprehensive mechanistic strategies such as non-systemic and systemic homing that revealed a significant role in cell therapy remodeling were also reviewed. Finally, the primary implications for the development of combination therapies that incorporate both MSCs and CAR-T cells for cancer treatment were discussed.

引用

页码：153 / 173

页数：21

共 176 条

[1] Homing to solid cancers: a vascular checkpoint in adoptive cell therapy using CAR T-cells [J].