Value of Safety of Anticoagulant Therapy in Elderly Patient with Atrial Fibrillation and High Risk of Bleeding

被引：0
作者：
Vorobyeva, N. M. [1 ]
Tkacheva, O. N. [1 ]
机构：
[1] Pirogov Russian Natl Res Med Univ, Moscow, Russia
来源：
RATIONAL PHARMACOTHERAPY IN CARDIOLOGY | 2023年 / 19卷 / 01期
关键词：
atrial fibrillation; elderly patient; rivaroxaban; safety; high risk of bleeding; ORAL ANTICOAGULANTS; RIVAROXABAN; WARFARIN; PREVENTION; EFFICACY; STROKE; POLYPHARMACY; METAANALYSIS; MORTALITY; EMBOLISM;
D O I：
10.20996/1819-6446-2023-01-02
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The review article discusses the safety issue of anticoagulant therapy in elderly patients with atrial fibrillation and high risk of bleeding. An evidence base is presented demonstrating the high safety of rivaroxaban in patients over 80 years of age, with a high risk of bleeding and cardiovascular com-plications, the presence of comorbid pathology, geriatric syndromes and chronic kidney disease (including in combination with anemia). The problem of low adherence to treatment in elderly patients and the possibility of solving it were separately considered.
引用
收藏
页码：101 / 106
页数：6
相关论文
共 29 条
[1]  
[Деменко Татьяна Николаевна Demenko T.N.], 2015, [Анналы аритмологии, Annaly aritmologii], V12, P215, DOI [10.15275/annaritmol.2015.4.3, 10.15275/annaritmol.2015.4.3]
[2]  
2022, Therapy, V10_2022, P23, DOI [10.18565/therapy.2021.10.23-41, 10.18565/therapy.2021.10.23-41, DOI 10.18565/THERAPY.2021.10.23-41]
[3]   Safety performance of rivaroxaban versus warfarin in patients with atrial fibrillation and advanced chronic kidney disease [J].
Chashkina, M., I ;
Andreev, D. A. ;
Kozlovskaya, N. L. ;
Salpagarova, Z. K. ;
Suvorov, A. Yu ;
Suchkova, S. A. ;
Bykova, A. A. ;
Syrkin, A. L. .
KARDIOLOGIYA, 2020, 60 (11) :94-100
[4]   Gastrointestinal bleeding in patients on novel oral anticoagulants: Risk, prevention and management [J].
Cheung, Ka-Shing ;
Leung, Wai K. .
WORLD JOURNAL OF GASTROENTEROLOGY, 2017, 23 (11) :1954-1963
[5]   Burden of major gastrointestinal bleeding among oral anticoagulant-treated non-valvular atrial fibrillation patients [J].
Deitelzweig, Steven ;
Keshishian, Allison ;
Kang, Amiee ;
Dhamane, Amol D. ;
Luo, Xuemei ;
Balachander, Neeraja ;
Rosenblatt, Lisa ;
Mardekian, Jack ;
Jiang, Jenny ;
Yuce, Huseyin ;
Lip, Gregory Y. H. .
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY, 2021, 14
[6]   Prevention of stroke and systemic embolism with rivaroxaban compared with warfarin in patients with non-valvular atrial fibrillation and moderate renal impairment [J].
Fox, Keith A. A. ;
Piccini, Jonathan P. ;
Wojdyla, Daniel ;
Becker, Richard C. ;
Halperin, Jonathan L. ;
Nessel, Christopher C. ;
Paolini, John F. ;
Hankey, Graeme J. ;
Mahaffey, Kenneth W. ;
Patel, Manesh R. ;
Singer, Daniel E. ;
Califf, Robert M. .
EUROPEAN HEART JOURNAL, 2011, 32 (19) :2387-2394
[7]   Frailty in older adults: Evidence for a phenotype [J].
Fried, LP ;
Tangen, CM ;
Walston, J ;
Newman, AB ;
Hirsch, C ;
Gottdiener, J ;
Seeman, T ;
Tracy, R ;
Kop, WJ ;
Burke, G ;
McBurnie, MA .
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2001, 56 (03) :M146-M156
[8]   Causes of Death in Anticoagulated Patients With Atrial Fibrillation [J].
Gomez-Outes, Antonio ;
Lagunar-Ruiz, Julian ;
Terleira-Fernandez, Ana-Isabel ;
Calvo-Rojas, Gonzalo ;
Luisa Suarez-Gea, Maria ;
Vargas-Castrillon, Emilio .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2016, 68 (23) :2508-2521
[9]   Efficacy and Safety of Rivaroxaban Compared With Warfarin Among Elderly Patients With Nonvalvular Atrial Fibrillation in the Rivaroxaban Once Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) [J].
Halperin, Jonathan L. ;
Hankey, Graeme J. ;
Wojdyla, Daniel M. ;
Piccini, Jonathan P. ;
Lokhnygina, Yuliya ;
Patel, Manesh R. ;
Breithardt, Guenter ;
Singer, Daniel E. ;
Becker, Richard C. ;
Hacke, Werner ;
Paolini, John F. ;
Nessel, Christopher C. ;
Mahaffey, Kenneth W. ;
Califf, Robert M. ;
Fox, Keith A. A. .
CIRCULATION, 2014, 130 (02) :138-U45
[10]  
Hanon O, 2020, ARCH CARDIOVAS DIS S, V12, P115, DOI [10.1016/j.acvdsp.2019.09.250, 10.1016/j.acvdsp.2019.09.250, DOI 10.1016/J.ACVDSP.2019.09.250]
123