Effectiveness of the α-tocopherol, ursodeoxycholic acid, and AZHEPOFIT phyto-complex against the statin model of drug-induced hepatitis

Background: Drug-induced hepatitis is a common and serious side effect of many medications. Treatment for this condition is often difficult and limited, and there is a need for effective treatment options. The aim of this study was to investigate the effectiveness of a-tocopherol acetate, ursodeoxycholic acid, and AZHEPOFIT phyto-complex against the background of a statin model of drug-induced hepatitis. Methods: The study was conducted on 70 white mongrel rats, divided into two groups and treated for 2 weeks twice a day. Statistical analysis was carried out by the Mann-Whitney-Wilcoxon method using MS EXCEL and S-PLUS software. Results: Against the background of the statin hepatitis model, the combined use of the phyto-complex and ursodeoxycholic acid showed the best results. The atherogenicity index decreased from 16.03 to 2.29, the De Ritis ratio decreased from up to 1.49 +/- 0.05, and the severity of lipid peroxidation, the content of c-reactive protein, and medium molecular weight peptides decreased. All of these results indicate the restoration of the functional state of the liver. Conclusion: The use of a-tocopherol acetate, ursodeoxycholic acid, and AZHEPOFIT phyto-complex can be an effective treatment option for drug-induced hepatitis caused by statin medication. The combination of phyto-complex and ursodeoxycholic acid showed the best results in reducing.