Preparation of poly (N-isopropylacrylamide)/polycaprolactone electrospun nanofibres as thermoresponsive drug delivery systems in wound dressing

被引：6

作者：

Li, Changgui ^{[1
]}

Qiu, Yuheng ^{[1
]}

Li, Rongguo ^{[1
]}

Li, Mengting ^{[1
]}

Qin, Ziyu ^{[1
]}

Yin, Xueqiong ^{[1
]}

机构：

[1] Hainan Univ, Hainan Prov Fine Chem Engn Res Ctr, Haikou 570228, Hainan, Peoples R China

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2023年 / 72卷 / 03期

基金：

海南省自然科学基金;

关键词：

Poly(N-isopropylacrylamide); electrospinning; thermoresponsive; drug delivery; wound dressing; MODIFIED LIPOSOMES; RELEASE; FIBERS; PCL; PERMEATION; MEMBRANES;

D O I：

10.1080/00914037.2021.2006654

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

A thermo-sensitive film composed of polycaprolactone and poly(N-isopropylacrylamide) was fabricated via electrospinning, with ketoconazole as the model drug. The morphology, elemental composition, and surface hydrophilicity of the nanofibres were characterized, and the results showed that nanofibres switched from a hydrophilic to a hydrophobic state as the temperature increased from 25 degrees C to 37 degrees C. The drug release profiles of the films suggested that sustained drug release behavior was achieved, and a lower temperature induced a faster delivery. Therefore, the prepared nanofibres could be highly applicable as wound dressings for on-demand and sustained drug release systems based on their temperature-responsive properties.

引用

页码：243 / 251

页数：9

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