A health technology assessment of personalized nutrition interventions using the EUnetHTA HTA Core Model

被引:2
作者
Galekop, Milanne Maria Johanna [1 ]
del Bas, Josep Maria [2 ]
Calder, Philip C. [3 ,4 ,5 ]
Uyl-De Groot, Carin A. [1 ]
Redekop, William Ken [1 ]
机构
[1] Erasmus Univ, Erasmus Sch Hlth Policy & Management, Rotterdam, Netherlands
[2] Eurecat Ctr Tecnol Catalunya, Biotechnol Area, Reus, Spain
[3] Univ Southampton, Fac Med, Sch Human Dev & Hlth, Southampton, England
[4] Univ Hosp Southampton NHS Fdn Trust, NIHR Southampton Biomed Res Ctr, Southampton, England
[5] Univ Southampton, Southampton, England
基金
欧盟地平线“2020”;
关键词
health technology assessment; personalized nutrition; obesity; HTA Core Model; prevention; COST-EFFECTIVENESS; OBESITY; ADULTS; OVERWEIGHT; DIET;
D O I
10.1017/S0266462324000060
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Objectives Poor nutrition links to chronic diseases, emphasizing the need for optimized diets. The EU-funded project PREVENTOMICS, introduced personalized nutrition to address this. This study aims to perform a health technology assessment (HTA) comparing personalized nutrition interventions developed through this project, with non-personalized nutrition interventions (control) for people with normal weight, overweight, or obesity. The goal is to support decisions about further development and implementation of personalized nutrition.Methods The PREVENTOMICS interventions were evaluated using the European Network for HTA Core Model, which includes a methodological framework that encompasses different domains for value assessment. Information was gathered via [1] different statistical analyses and modeling studies, [2] questions asked of project partners and, [3] other (un)published materials.Results Clinical trials of PREVENTOMICS interventions demonstrated different body mass index changes compared to control; differences ranged from -0.80 to 0.20 kg/m2. Long-term outcome predictions showed generally improved health outcomes for the interventions; some appeared cost-effective (e.g., interventions in UK). Ethical concerns around health inequality and the lack of specific legal regulations for personalized nutrition interventions were identified. Choice modeling studies indicated openness to personalized nutrition interventions; decisions were primarily affected by intervention's price.Conclusions PREVENTOMICS clinical trials have shown promising effectiveness with no major safety concerns, although uncertainties about effectiveness exist due to small samples (n=60-264) and short follow-ups (10-16 weeks). Larger, longer trials are needed for robust evidence before implementation could be considered. Among other considerations, developers should explore financing options and collaborate with policymakers to prevent exclusion of specific groups due to information shortages.
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页数:13
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