The role of microRNAs in brain metastasis

被引：12

作者：

Hudson, Kadie ^{[1
]}

Mondia, Mark Willy ^{[2
]}

Zhang, Ying ^{[1
]}

Saha, Shekhar ^{[1
]}

Gibert Jr, Myron K. ^{[1
]}

Dube, Collin ^{[1
]}

Sun, Yunan ^{[1
]}

Marcinkiewicz, Pawel ^{[1
]}

Fadul, Camilo ^{[2
]}

Abounader, Roger ^{[3
]}

机构：

[1] Univ Virginia, Dept Microbiol Immunol & Canc Biol, Charlottesville, VA USA

[2] Univ Virginia, Dept Neurol, Charlottesville, VA USA

[3] Univ Virginia, Univ Virginia Canc Ctr, Dept Microbiol Immunol & Canc Biol, Dept Neurol, Charlottesville, VA 22903 USA

来源：

JOURNAL OF NEURO-ONCOLOGY | 2024年 / 166卷 / 02期

基金：

美国国家卫生研究院;

关键词：

microRNAs; Brain; Metastasis; Biomarkers; Targets; Therapy; BLOOD-TUMOR BARRIER; EXPRESSION CHANGES; CELL-MIGRATION; CANCER CELLS; BREAST; LUNG; PERMEABILITY; INVASION; GROWTH; PROLIFERATION;

D O I：

10.1007/s11060-023-04541-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Brain metastasis (BM) is the most common type of brain tumor and frequently foreshadows disease progression and poor overall survival with patients having a median survival of 6 months. 70,000 new cases of BM are diagnosed each year in the United States (US) and the incidence rate for BM is increasing with improved detection. MicroRNAs (miRNAs) are small non-coding RNAs that serve as critical regulators of gene expression and can act as powerful oncogenes and tumor suppressors. MiRNAs have been heavily implicated in cancer and proposed as biomarkers or therapeutic targets or agents. In this review, we summarize an extensive body of scientific work investigating the role of microRNAs in BM. We discuss miRNA dysregulation, functions, targets, and mechanisms of action in BM and present the current standing of miRNAs as biomarkers and potential therapeutics for BM. We conclude with future directions of miRNA basic and clinical research in BM.

引用

页码：231 / 241

页数：11

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