Microglial APOE4: more is less and less is more

被引：6

作者：

Eskandari-Sedighi, Ghazaleh ^{[1
,2
]}

Blurton-Jones, Mathew ^{[1
,2
,3
]}

机构：

[1] Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, Irvine, CA 92697 USA

[2] Univ Calif Irvine, Sue & Bill Gross Stem Cell Res Ctr, Irvine, CA 92697 USA

[3] Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA

来源：

MOLECULAR NEURODEGENERATION | 2023年 / 18卷 / 01期

关键词：

Apolipoprotein E; Microglia; APOE4; APOE3; Alzheimer's disease; Lgals3; TGF beta; GENE;

D O I：

10.1186/s13024-023-00693-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Apolipoprotein E (APOE) is the single greatest genetic risk factor for late onset Alzheimer's disease (AD). Yet, the cell-specific effects of APOE on microglia function have remained unclear. Fortunately, two comprehensive new studies published in the latest issue of Nature Immunology have employed complementary gain-of-function and loss-of-function approaches to provide critical new insight into the impact of microglial APOE on AD pathogenesis.

引用

页数：4

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