Targeted transcutaneous spinal cord stimulation promotes persistent recovery of upper limb strength and tactile sensation in spinal cord injury: a pilot study

被引:13
作者
Chandrasekaran, Santosh [1 ]
Bhagat, Nikunj A. [1 ,2 ]
Ramdeo, Richard [1 ]
Ebrahimi, Sadegh [1 ]
Sharma, Pawan D. [3 ]
Griffin, Doug G. [4 ]
Stein, Adam [5 ]
Harkema, Susan J. [3 ,6 ,7 ,8 ]
Bouton, Chad E. [1 ,9 ]
机构
[1] Northwell Hlth, Feinstein Inst Med Res, Inst Bioelect Med, Neural Bypass & Brain Comp Interface Lab, Manhasset, NY 11030 USA
[2] Univ Texas Hlth Sci Ctr, Dept Phys Med & Rehabil, Houston, TX USA
[3] Univ Louisville, Kentucky Spinal Cord Injury Res Ctr, Louisville, KY USA
[4] Northwell Hlth STARS Rehabil, East Meadow, NY USA
[5] Northwell Hlth, Donald & Barbara Zucker Sch Med Hofstra, Dept Phys Med & Rehabil, Manhasset, NY USA
[6] Univ Louisville, Dept Bioengn, Louisville, KY USA
[7] Univ Louisville Hlth, Frazier Rehabil Inst, Louisville, KY USA
[8] Univ Louisville, Dept Neurol Surg, Louisville, KY USA
[9] Donald & Barbara Zucker Sch Med Hofstra Northwell, Manhasset, NY 11030 USA
关键词
spinal cord injury; spinal cord stimulation; brain computer interface; selective stimulation; neuromodulation; neurostimulation devices; electrode array; paralysis; EPIDURAL ELECTRICAL-STIMULATION; HAND FUNCTION; MOVEMENT; HUMANS; BRAIN;
D O I
10.3389/fnins.2023.1210328
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Long-term recovery of limb function is a significant unmet need in people with paralysis. Neuromodulation of the spinal cord through epidural stimulation, when paired with intense activity-based training, has shown promising results toward restoring volitional limb control in people with spinal cord injury. Non-invasive neuromodulation of the cervical spinal cord using transcutaneous spinal cord stimulation (tSCS) has shown similar improvements in upper-limb motor control rehabilitation. However, the motor and sensory rehabilitative effects of activating specific cervical spinal segments using tSCS have largely remained unexplored. We show in two individuals with motor-complete SCI that targeted stimulation of the cervical spinal cord resulted in up to a 1,136% increase in exerted force, with weekly activity-based training. Furthermore, this is the first study to document up to a 2-point improvement in clinical assessment of tactile sensation in SCI after receiving tSCS. Lastly, participant gains persisted after a one-month period void of stimulation, suggesting that targeted tSCS may lead to persistent recovery of motor and sensory function.
引用
收藏
页数:10
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