Mitophagy alleviates cisplatin-induced renal tubular epithelial cell ferroptosis through ROS/HO-1/GPX4 axis

被引：139

作者：

Lin, Qisheng ^{[1
,4
]}

Li, Shu ^{[1
]}

Jin, Haijiao ^{[1
]}

Cai, Hong ^{[1
]}

Zhu, Xuying ^{[1
]}

Yang, Yuanting ^{[1
]}

Wu, Jingkui ^{[2
]}

Qi, Chaojun ^{[1
]}

Shao, Xinghua ^{[1
]}

Li, Jialin ^{[1
]}

Zhang, Kaiqi ^{[1
]}

Zhou, Wenyan ^{[1
]}

Zhang, Minfang ^{[1
]}

Cheng, Jiayi ^{[3
]}

Gu, Leyi ^{[1
]}

Mou, Shan ^{[1
]}

Ni, Zhaohui ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Ren Ji Hosp, Uremia Diag & Treatment Ctr, Dept Nephrol Mol Cell Lab Kidney Dis,Sch Med,Shang, Shanghai 200127, Peoples R China

[2] Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Dept Nephrol, Shanghai 201200, Peoples R China

[3] Tianping Community Hlth Serv Ctr, Shanghai 200031, Peoples R China

[4] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Nephrol, 160 Pu Jian Rd, Shanghai 200127, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2023年 / 19卷 / 04期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

Acute kidney injury; cisplatin nephrotoxicity; ferroptosis; mitophagy; ACUTE KIDNEY INJURY; AUTOPHAGY;

D O I：

10.7150/ijbs.80775

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cisplatin is widely recommended in combination for the treatment of tumors, thus inevitably increasing the incidence of cisplatin-induced acute kidney injury. Mitophagy is a type of mitochondrial quality control mechanism that degrades damaged mitochondria and maintains cellular homeostasis. Ferroptosis, a new modality of programmed cell death, is characterized by iron-dependent phospholipid peroxidation and oxidative membrane damage. However, the role of mitophagy in ferroptosis in kidney disease is unclear. Here, we investigated the mechanism underlying both BNIP3-mediated and PINK1-PARK2-mediated mitophagy-induced attenuation of ferroptosis in cisplatin-induced acute kidney injury. The results showed peroxidation and ferroptosis in the kidney, which were aggravated in Bnip3 knockout, Pink1 knockout or Park2 knockout cisplatin-treated mice. Ferrstatin-1, a synthetic antioxidative ferroptosis inhibitor, rescued iron accumulation, lipid peroxidation and ferroptosis caused by inhibition of mitophagy. Thus, the present study elucidated a novel mechanism by which both BNIP3-mediated and PINK1-PARK2mediated mitophagy protects against cisplatin-induced renal tubular epithelial cell ferroptosis through the

引用

页码：1192 / 1210

页数：19

共 66 条

[1] Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice [J].

Angeli, Jose Pedro Friedmann ;

Schneider, Manuela ;

Proneth, Bettina ;

Tyurina, Yulia Y. ;

Tyurin, Vladimir A. ;

Hammond, Victoria J. ;

Herbach, Nadja ;

Aichler, Michaela ;

Walch, Axel ;

Eggenhofer, Elke ;

Basavarajappa, Devaraj ;

Radmark, Olof ;

Kobayashi, Sho ;

Seibt, Tobias ;

Beck, Heike ;

Neff, Frauke ;

Esposito, Irene ;

Wanke, Ruediger ;

Foerster, Heidi ;

Yefremova, Olena ;

Heinrichmeyer, Marc ;

Bornkamm, Georg W. ;

Geissler, Edward K. ;

Thomas, Stephen B. ;

Stockwell, Brent R. ;

O'Donnell, Valerie B. ;

Kagan, Valerian E. ;

Schick, Joel A. ;

Conrad, Marcus .

NATURE CELL BIOLOGY, 2014, 16 (12) :1180-U120

[2] Autophagy Induces Prosenescent Changes in Proximal Tubular S3 Segments [J].

Baisantry, Arpita ;

Bhayana, Sagar ;

Rong, Song ;

Ermeling, Esther ;

Wrede, Christoph ;

Hegermann, Jan ;

Pennekamp, Petra ;

Soerensen-Zender, Inga ;

Haller, Hermann ;

Melk, Anette ;

Schmitt, Roland .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2016, 27 (06) :1609-1616

[3] AMPK mediates regulation of glomerular volume and podocyte survival [J].

Banu, Khadija ;

Lin, Qisheng ;

Basgen, John M. ;

Planoutene, Marina ;

Wei, Chengguo ;

Reghuvaran, Anand C. ;

Tian, Xuefei ;

Shi, Hongmei ;

Garzon, Felipe ;

Garzia, Aitor ;

Chun, Nicholas ;

Cumpelik, Arun ;

Santeusanio, Andrew D. ;

Zhang, Weijia ;

Das, Bhaskar ;

Salem, Fadi ;

Li, Li ;

Ishibe, Shuta ;

Cantley, Lloyd G. ;

Kaufman, Lewis ;

Lemley, Kevin V. ;

Ni, Zhaohui ;

He, John Cijiang ;

Murphy, Barbara ;

Menon, Madhav C. .

JCI INSIGHT, 2021, 6 (19)

[4] Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells [J].

Basit, Farhan ;

van Oppen, Lisanne M. P. E. ;

Schoeckel, Laura ;

Bossenbroek, Hasse M. ;

van Emst-de Vries, Sjenet E. ;

Hermeling, Johannes C. W. ;

Grefte, Sander ;

Kopitz, Charlotte ;

Heroult, Melanie ;

Willems, Peter H. G. M. ;

Koopman, Werner J. H. .

CELL DEATH & DISEASE, 2017, 8 :e2716-e2716

[5] Autophagy during viral infection - a double-edged sword [J].

Choi, Younho ;

Bowman, James W. ;

Jung, Jae U. .

NATURE REVIEWS MICROBIOLOGY, 2018, 16 (06) :340-353

[6] Myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule [J].

Deng, Fei ;

Sharma, Isha ;

Dai, Yingbo ;

Yang, Ming ;

Kanwar, Yashpal S. .

JOURNAL OF CLINICAL INVESTIGATION, 2019, 129 (11) :5033-5049

[7] Mitochondrial Iron Overload-Mediated Inhibition of Nrf2-HO-1/GPX4 Assisted ALI-Induced Nephrotoxicity [J].

Deng, Hui-Fang ;

Yue, Lan-Xin ;

Wang, Ning-Ning ;

Zhou, Yong-Qiang ;

Zhou, Wei ;

Liu, Xian ;

Ni, Yu-Hao ;

Huang, Cong-Shu ;

Qiu, Li-Zhen ;

Liu, Hong ;

Tan, Hong-Ling ;

Tang, Xiang-Lin ;

Wang, Yu-Guang ;

Ma, Zeng-Chun ;

Gao, Yue .

FRONTIERS IN PHARMACOLOGY, 2021, 11

[8] Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice [J].

Diwan, Abhinav ;

Krenz, Maike ;

Syed, Faisal M. ;

Wansapura, Janaka ;

Ren, Xiaoping ;

Koesters, Andrew G. ;

Li, Hairong ;

Kirshenbaum, Lorrie A. ;

Hahn, Harvey S. ;

Robbins, Jeffrey ;

Jones, W. Keith ;

Dorn, Gerald W., II .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (10) :2825-2833

[9] Life, death and autophagy [J].

Doherty, Johnna ;

Baehrecke, Eric H. .

NATURE CELL BIOLOGY, 2018, 20 (10) :1110-1117

[10]

Evans TD., 2017, Sci Signal, P10

← 1 2 3 4 5 6 7 →