Quisqualis indica extract for men with lower urinary tract symptoms: A randomized, double-blind, placebo-controlled trial

被引：3

作者：

Shin, Dongho ^{[1
]}

Zhu, Guan Qun ^{[2
,3
]}

Tian, Wen Jie ^{[2
]}

Ahn, Sun Tae ^{[4
]}

Jeon, Seung Hwan ^{[2
]}

Cho, Hyuk Jin ^{[1
]}

Ha, U-Syn ^{[1
]}

Hong, Sung-Hoo ^{[1
]}

Lee, Ji Youl ^{[1
]}

Kim, Sae Woong ^{[1
,2
]}

Moon, Du Geon ^{[4
,6
]}

Bae, Woong Jin ^{[1
,2
,5
]}

机构：

[1] Catholic Univ Korea, Seoul St MarysHospital, Coll Med, Dept Urol, Seoul St, Seoul, South Korea

[2] Catholic Univ Korea, Catholic Integrat Med Res Inst, Coll Med, Seoul, South Korea

[3] Qingdao Univ, Affiliated Hosp, Dept Urol, Qingdao, Shandong, Peoples R China

[4] Korea Univ, Coll Med, Dept Urol, Seoul, South Korea

[5] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Urol, Seoul St,222 Banpo daero, Seoul 06591, South Korea

[6] Korea Univ, Korea Univ Guro Hosp, Coll Med, Dept Urol, 148 Gurodong ro,Guro gu, Seoul, South Korea

来源：

INVESTIGATIVE AND CLINICAL UROLOGY | 2023年 / 64卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Dihydrotestosterone; Pharmacologic effects; Plant extract; Safety; BENIGN PROSTATIC HYPERPLASIA; ERECTILE DYSFUNCTION; SECONDARY; EFFICACY; BPH;

D O I：

10.4111/icu.20220290

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose: To evaluate the efficacy and safety of Quisqualis indica in men with moderate lower urinary tract symptoms (LUTS). Materials and Methods: A total of 135 subjects with International Prostate Symptom Score (IPSS) of 8-19 were randomized in 2 centers from June 2018 to April 2019. Patients were assigned into one of the three groups: a low-dose group (LG, 1,000 mg Q. indica), a high-dose group (HG, 2,000 mg Q. indica) or a placebo group (PG). The primary endpoint was the change of IPSS at the end of treatment from baseline. Secondary end points included the changes of prostate specific antigen, testosterone, dihydrotestosterone, maximum urinary flow rate (Qmax), postvoid residual volume (PVR) and International Index of Erectile Function-5 (IIEF-5), with drug safety. Results: 113 patients were able to finish the study. Compared to the PG, total IPSS in the LG and the HG was significantly improved at 6 weeks and 12 weeks. For IPSS subscores, LG showed improvements in all except for urgency and quality of life at 6 weeks. HG showed improvements in incomplete emptying and frequency at 6 weeks and 12 weeks along with improvements in intermittency, straining, and quality of life at 12 weeks. For IIEF-5 subscores, orgasmic function and overall satisfaction improved in HG when compared to PG at 12 weeks. Lastly, increase of Qmax and decrease of PVR was observed at 6 weeks in LG. Conclusions: 12-week treatment with Q. indica has a therapeutic effect and is well tolerated in patients with LUTS.

引用

页码：20 / 30

页数：11

共 30 条

[1] Is There Evidence of a Relationship between Benign Prostatic Hyperplasia and Prostate Cancer? Findings of a Literature Review [J].