Recent Advances in Studying Toll-like Receptors with the Use of Computational Methods

被引：9

作者：

Bzowka, Maria ^{[1
,2
]}

Bagrowska, Weronika ^{[2
]}

Gora, Artur ^{[2
]}

机构：

[1] Silesian Tech Univ, Fac Chem, Dept Organ Chem Bioorgan Chem & Biotechnol, PL-44100 Gliwice, Poland

[2] Silesian Tech Univ, Biotechnol Ctr, Tunneling Grp, 44100, Gliwice, Poland

来源：

JOURNAL OF CHEMICAL INFORMATION AND MODELING | 2023年 / 63卷 / 12期

关键词：

immune response; pattern recognition receptors; small-molecule modulators; Toll-like receptors; vaccine design; protein-ligand interactions; protein-protein interactions signaling; PATTERN-RECOGNITION RECEPTORS; MULTI-EPITOPE VACCINE; CRYSTAL-STRUCTURE; STRUCTURAL BASIS; PREDICTION; AGONISTS; ANTAGONISTS; DESIGN; TRANSMEMBRANE; INFLAMMATION;

D O I：

10.1021/acs.jcim.3c00419

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Toll-like receptors (TLRs) are transmembrane proteinsthat recognizevarious molecular patterns and activate signaling that triggers theimmune response. In this review, our goal is to summarize how, inrecent years, various computational solutions have contributed toa better understanding of TLRs, regarding both their function andmechanism of action. We update the recent information about small-moleculemodulators and expanded the topic toward next-generation vaccine design,as well as studies of the dynamic nature of TLRs. Also, we underlineproblems that remain unsolved.

引用

页码：3669 / 3687

页数：19

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