Crucial Regulatory Role of Organokines in Relation to Metabolic Changes in Non-Diabetic Obesity

被引:15
作者
Lorincz, Hajnalka [1 ]
Somodi, Sandor [2 ,3 ]
Ratku, Balazs [2 ,3 ,4 ]
Harangi, Mariann [1 ,3 ]
Paragh, Gyoergy [1 ]
机构
[1] Univ Debrecen, Fac Med, Dept Internal Med, Div Metab Dis, H-4032 Debrecen, Hungary
[2] Univ Debrecen, Fac Med, Dept Emergency Med, H-4032 Debrecen, Hungary
[3] Univ Debrecen, Inst Hlth Stud, Fac Hlth Sci, H-4032 Debrecen, Hungary
[4] Univ Debrecen, Doctoral Sch Hlth Sci, H-4032 Debrecen, Hungary
关键词
metabolically healthy obesity; non-diabetic obesity; adipokine; hepatokine; myokine; sarcopenic obesity; prediabetes; insulin resistance; cardiovascular risk; PLASMINOGEN-ACTIVATOR INHIBITOR-1; EPITHELIUM-DERIVED FACTOR; GROWTH-FACTOR; 21; TYPE-2; DIABETES-MELLITUS; SERINE-PROTEASE INHIBITOR; EARLY RENAL INJURY; FETUIN-A LEVELS; ADIPOSE-TISSUE; INSULIN-RESISTANCE; METEORIN-LIKE;
D O I
10.3390/metabo13020270
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Obesity is characterized by an excessive accumulation of fat leading to a plethora of medical complications, including coronary artery disease, hypertension, type 2 diabetes mellitus or impaired glucose tolerance and dyslipidemia. Formerly, several physiological roles of organokines, including adipokines, hepatokines, myokines and gut hormones have been described in obesity, especially in the regulation of glucose and lipid metabolism, insulin sensitivity, oxidative stress, and low-grade inflammation. The canonical effect of these biologically active peptides and proteins may serve as an intermediate regulatory level that connects the central nervous system and the endocrine, autocrine, and paracrine actions of organs responsible for metabolic and inflammatory processes. Better understanding of the function of this delicately tuned network may provide an explanation for the wide range of obesity phenotypes with remarkable inter-individual differences regarding comorbidities and therapeutic responses. The aim of this review is to demonstrate the role of organokines in the lipid and glucose metabolism focusing on the obese non-diabetic subgroup. We also discuss the latest findings about sarcopenic obesity, which has recently become one of the most relevant metabolic disturbances in the aging population.
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页数:27
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