The emerging role and therapeutic implications of bacterial and parasitic deubiquitinating enzymes

被引：5
作者：
Wehrmann, Markus [1 ,2 ]
Vilchez, David [1 ,2 ,3 ,4 ]
机构：
[1] Univ Cologne, Cologne Excellence Cluster Cellular Stress Respons, Cologne, Germany
[2] Univ Hosp Cologne, Inst Integrated Stress Response Signaling, Fac Med, Cologne, Germany
[3] Univ Cologne, Ctr Mol Med Cologne CMMC, Cologne, Germany
[4] Univ Cologne, Inst Genet, Cologne, Germany
来源：
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
关键词：
ubiquitin; deubiquitinating enzymes (DUBs); infection mechanisms; immune responses; autophagy and apoptosis; NF-KAPPA-B; UBIQUITIN; SUPPRESSION; HYDROLASE; AUTOPHAGY; FAMILY; A20;
D O I：
10.3389/fimmu.2023.1303072
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Deubiquitinating enzymes (DUBs) are emerging as key factors for the infection of human cells by pathogens such as bacteria and parasites. In this review, we discuss the most recent studies on the role of deubiquitinase activity in exploiting and manipulating ubiquitin (Ub)-dependent host processes during infection. The studies discussed here highlight the importance of DUB host-pathogen research and underscore the therapeutic potential of inhibiting pathogen-specific DUB activity to prevent infectious diseases.
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页数：8
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