Pharmacokinetics, efficacy, and safety of cannabidiol in dogs: an update of current knowledge

被引:12
作者
Di Salvo, Alessandra [1 ]
Conti, Maria Beatrice [1 ]
della Rocca, Giorgia [1 ]
机构
[1] Ctr Studio Dolore Anim CeRiDA, Dipartimento Med Vet Perugia, Perugia, Italy
关键词
phytocannabinoids; cannabidiol; CBD; dog; pharmacokinetics; efficacy; tolerability; CANINE ATOPIC-DERMATITIS; PAIN; RECEPTOR; CANNABINOIDS; ENDOCANNABINOIDS; EPILEPSY; PALMITOYLETHANOLAMIDE; INFLAMMATION; RESPONSES; DELIVERY;
D O I
10.3389/fvets.2023.1204526
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
In the last 5 years, interest has grown in using phytocannabinoids, particularly cannabidiol (CBD), in veterinary medicine to treat several pathologies, including pain, epilepsy, anxiety, nausea, anorexia, skin lesions, and even some types of cancer, among others. Indeed, due to a positive perception of CBD use, many pet owners are increasingly requesting this option to relieve their pets, and many veterinarians are exploring this possibility for their patients. Besides the widespread empiric use of CBD in pets, the research is trying to obtain proof of its efficacy and lack of adverse effects and to know its pharmacokinetics to define an appropriate posology. This review summarizes all data published so far about the canine pharmacokinetics, efficacy, and tolerability of CBD and cannabidiolic acid (CBDA). Despite a certain number of available pharmacokinetic studies, the kinetic profile of CBD has yet to be fully known, probably because of the very different experimental conditions. In terms of efficacy, most studies have tested CBD' ability to relieve osteoarthritic pain. In contrast, few studies have evaluated its role in epilepsy, behavioral disorders, and skin lesions. From obtained results, some evidence exists supporting the beneficial role of CBD. Nevertheless, the limited number of published studies and the occurrence of bias in almost all require caution in interpreting findings. From tolerability studies, CBD' side effects can be classified as mild or unremarkable. However, studies were prevalently focused on short- to medium-term treatment, while CBD is usually employed for long-term treatment. Further studies are warranted to define better whether CBD could be a valid adjunct in canine treatment.
引用
收藏
页数:15
相关论文
共 102 条
[1]   Scientific Validation of Cannabidiol for Management of Dog and Cat Diseases [J].
Alvarenga, Isabella Corsato ;
Panickar, Kiran S. ;
Hess, Hannah ;
McGrath, Stephanie .
ANNUAL REVIEW OF ANIMAL BIOSCIENCES, 2023, 11 :227-246
[2]   Cannabis constituents interact at the drug efflux pump BCRP to markedly increase plasma cannabidiolic acid concentrations [J].
Anderson, Lyndsey L. ;
Etchart, Maia G. ;
Bahceci, Dilara ;
Golembiewski, Taliesin A. ;
Arnold, Jonathon C. .
SCIENTIFIC REPORTS, 2021, 11 (01)
[3]   Expression of functional TRPV1 receptor in primary culture of canine keratinocytes [J].
Barbero, Raffaella ;
Vercelli, Cristina ;
Cuniberti, Barbara ;
della Valle, Maria Federica ;
Martano, Marina ;
Re, Giovanni .
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 2018, 41 (06) :795-804
[4]  
Bartner LR, 2018, CAN J VET RES, V82, P178
[5]   Pharmacology of cannabinoids: applications for pain treatment? [J].
Beaulieu, P ;
Rice, ASC .
ANNALES FRANCAISES D ANESTHESIE ET DE REANIMATION, 2002, 21 (06) :493-508
[6]   Cannabidiol as a Potential Treatment for Anxiety Disorders [J].
Blessing, Esther M. ;
Steenkamp, Maria M. ;
Manzanares, Jorge ;
Marmar, Charles R. .
NEUROTHERAPEUTICS, 2015, 12 (04) :825-836
[7]   EFFECT OF CANNABIDIOL ON CYTOCHROME-P-450 ISOZYMES [J].
BORNHEIM, LM ;
CORREIA, MA .
BIOCHEMICAL PHARMACOLOGY, 1989, 38 (17) :2789-2794
[8]   Long-term daily feeding of cannabidiol is well-tolerated by healthy dogs [J].
Bradley, Sophie ;
Young, Scott ;
Bakke, Anne Marie ;
Holcombe, Lucy ;
Waller, Daniel ;
Hunt, Alysia ;
Pinfold, Kathleen ;
Watson, Phillip ;
Logan, Darren W. .
FRONTIERS IN VETERINARY SCIENCE, 2022, 9
[9]   Oral Transmucosal Cannabidiol Oil Formulation as Part of a Multimodal Analgesic Regimen: Effects on Pain Relief and Quality of Life Improvement in Dogs Affected by Spontaneous Osteoarthritis [J].
Brioschi, Federica Alessandra ;
Di Cesare, Federica ;
Gioeni, Daniela ;
Rabbogliatti, Vanessa ;
Ferrari, Francesco ;
D'Urso, Elisa Silvia ;
Amari, Martina ;
Ravasio, Giuliano .
ANIMALS, 2020, 10 (09) :1-14
[10]   Potential Adverse Drug Events and Drug-Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use [J].
Brown, Joshua D. ;
Winterstein, Almut G. .
JOURNAL OF CLINICAL MEDICINE, 2019, 8 (07)