Spiro-Josiphos Ligands for the Ir-Catalyzed Asymmetric Synthesis of Chiral Amines under Hydrogenation Conditions

被引：3

作者：

Li, Bin ^{[1
]}

Zhou, Gang ^{[2
]}

Zhang, Dongxu ^{[2
]}

Yao, Lin ^{[2
]}

Li, Muqiong ^{[2
]}

Yang, Guidong ^{[1
]}

Zhang, Shengyong ^{[1
,2
]}

Nie, Huifang ^{[2
]}

机构：

[1] Xi An Jiao Tong Univ, Sch Chem Engn & Technol, XJTU Oxford Int Joint Lab Catalysis, Xian 710049, Shaanxi, Peoples R China

[2] Fourth Mil Med Univ, Sch Pharm, Dept Med Chem, Xian 710032, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 10期

基金：

中国国家自然科学基金;

关键词：

HIGHLY ENANTIOSELECTIVE HYDROGENATION; FACILE SYNTHESIS; COMPLEXES; QUINOLINES; ALKALOIDS; EFFICIENT; IMINES; ISOQUINOLINES; QUINOXALINES; SALTS;

D O I：

10.1021/acs.orglett.4c00409

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Transition metal-catalyzed asymmetric hydrogenation possesses unparalleled advantages to prepare chiral amines. Here we reported a novel ligand that combined Josiphos and a spirobiindane scaffold and simultaneously investigated its application in Ir-catalyzed asymmetric hydrogenation for the synthesis of chiral amines. Excellent catalytic activity (5000 TON), high enantioselectivity (up to 99% ee), and broad substrate scope (different C=N substrates) make it highly promising for both academic research and industrial applications.

引用

收藏

页码：2097 / 2102

页数：6

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