Secondary metabolites from the deep-sea derived fungus Aspergillus terreus MCCC M28183

被引：4

作者：

Huang, Xiaomei ^{[1
,2
]}

Wang, Yichao ^{[3
,4
]}

Li, Guangyu ^{[2
]}

Shao, Zongze ^{[2
]}

Xia, Jinmei ^{[2
]}

Qin, Jiang-Jiang ^{[3
]}

Wang, Weiyi ^{[2
]}

机构：

[1] Xiamen Ocean Vocat Coll, Dept Marine Biol, Xiamen Key Lab Intelligent Fishery, Xiamen, Peoples R China

[2] Minist Nat Resources, Inst Oceanog 3, Key Lab Marine Biogenet Resources, Xiamen, Peoples R China

[3] Chinese Acad Sci, Zhejiang Canc Hosp, Hangzhou Inst Med HIM, Hangzhou, Peoples R China

[4] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou, Peoples R China

来源：

FRONTIERS IN MICROBIOLOGY | 2024年 / 15卷

关键词：

Aspergillus; secondary metabolites; cytotoxic; antibacterial; deep-sea; XANTHONE DERIVATIVES; ASSIGNMENT;

D O I：

10.3389/fmicb.2024.1361550

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aspergillus fungi are renowned for producing a diverse range of natural products with promising biological activities. These include lovastatin, itaconic acid, terrin, and geodin, known for their cholesterol-regulating, anti-inflammatory, antitumor, and antibiotic properties. In our current study, we isolated three dimeric nitrophenyl trans-epoxyamides (1-3), along with fifteen known compounds (4-18), from the culture of Aspergillus terreus MCCC M28183, a deep-sea-derived fungus. The structures of compounds 1-3 were elucidated using a combination of NMR, MS, NMR calculation, and ECD calculation. Compound 1 exhibited moderate inhibitory activity against human gastric cancer cells MKN28, while compound 7 showed similar activity against MGC803 cells, with both showing IC50 values below 10 mu M. Furthermore, compound 16 exhibited moderate potency against Vibrio parahaemolyticus ATCC 17802, with a minimum inhibitory concentration (MIC) value of 7.8 mu g/mL. This promising research suggests potential avenues for developing new pharmaceuticals, particularly in targeting specific cancer cell lines and combating bacterial infections, leveraging the unique properties of these Aspergillus-derived compounds.

引用

页数：10

共 31 条

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