New binuclear Cu (II) complex: synthesis, structural elucidation, cytotoxic and DNA-binding evaluation

被引：2

作者：

Hussein, Mouayed A. ^{[1
]}

Yaseen, Adyan A. ^{[1
]}

机构：

[1] Univ Basrah, Coll Sci, Dept Chem, Basrah 6100, Iraq

来源：

TRANSITION METAL CHEMISTRY | 2024年 / 49卷 / 01期

关键词：

CRYSTAL-STRUCTURE; COPPER(II) COMPLEXES; CU(II) COMPLEX; BSA-BINDING; ANTICANCER; CLEAVAGE; LIGANDS; DNA/BSA; 1,10-PHENANTHROLINE; ACID;

D O I：

10.1007/s11243-023-00561-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A novel copper complex [Cu(mu 2-OH)(1,10-phenanthroline)(4-aminobenzenesulfonic acid)center dot 3H2O]2 (1) was synthesized and characterized by X-ray single-crystal diffraction, elemental analysis and IR spectroscopy. X-ray crystallography of complex 1 showed strictly planar bridged mu 2-Cu2(OH)2 core where copper (II) center exhibited a distorted square pyramidal coordination geometry. The interaction of the complex with calf thymus DNA (CT DNA) was investigated by absorption titration and viscosity measurement. The results revealed an intercalation binding between DNA and complex 1 with a binding strength of 6.0731 x 106 +/- 0.0032 M-1. The antitumor capacity of the complex was tested in vitro against human colorectal (HCT 116) cancer cell lines by metabolic tests, using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide reagent. Complex 1 showed remarkably low IC50 values of 4.844 +/- 0.025 mu M compared to 5-fluorouracil (7.3 mu M), a widely used clinical antitumor drug.

引用

页码：53 / 62

页数：10

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