Henry reaction catalyzed by recyclable polyamine

被引：1

作者：

Lv, Bingqing ^{[1
]}

Feng, Qixun ^{[1
]}

Cai, Pengcheng ^{[1
]}

Chen, Guoliang ^{[1
]}

Bao, Xuefei ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China

来源：

TETRAHEDRON LETTERS | 2023年 / 124卷

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

Henry reaction; Polyamine; Catalysis; Nitroaldol addition; 3-dinitroalkanes; ASYMMETRIC HENRY;

D O I：

10.1016/j.tetlet.2023.154557

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The catalytic Henry reaction is an important CAC bond forming reaction between aldehyde/ketone and nitroalkane. Herein, a metal-free recyclable polyamine JP-2Y was developed and various /3-nitroalcohols were prepared with acceptable yields (up to 91%) via the Henry reaction catalyzed by JP-2Y. In addition, for nitromethane, the protocol can be used for selective preparation of /3-nitro alcohols or 1,3-dinitroalka-nes by adjusting the reaction temperature and additive. The recyclability of JP-2Y was proved via catalyz-ing the reaction at gram-scale for at least 8 consecutive runs.& COPY; 2023 Elsevier Ltd. All rights reserved.

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页数：7

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