Synthesis of Methotrexate-Loaded Dumbbell-Shaped Titanium Dioxide/Gold Nanorods Coated with Mesoporous Silica and Decorated with Upconversion Nanoparticles for Near-Infrared-Driven Trimodal Cancer Treatment

被引：22

作者：

Dash, Pranjyan ^{[1
]}

Thirumurugan, Senthilkumar ^{[1
]}

Tseng, Ching-Li ^{[2
,3
,4
]}

Lin, Yu-Chien ^{[1
]}

Chen, Sung-Lung ^{[1
]}

Dhawan, Udesh ^{[5
]}

Chung, Ren-Jei ^{[1
,6
]}

机构：

[1] Natl Taipei Univ Technol Taipei Tech, Dept Chem Engn & Biotechnol, Taipei 10608, Taiwan

[2] Taipei Med Univ, Grad Inst Biomed Mat & Tissue Engn, Coll Biomed Engn, Taipei 110, Taiwan

[3] Taipei Med Univ, Coll Biomed Engn, Int PhD Program Biomed Engn, Res Ctr Biomed Device, Taipei 110, Taiwan

[4] Taipei Med Univ, Coll Med, Int PhD Program Cell Therapy & Regenerat Med, Taipei 110, Taiwan

[5] Univ Glasgow, Ctr Cellular Microenvironm, Mazumdar Shaw Adv Res Ctr, James Watt Sch Engn,Div Biomed Engn, Glasgow G116EW, Scotland

[6] Natl Taipei Univ Technol Taipei Tech, High Value Biomat Res & Commercializat Ctr, Taipei 10608, Taiwan

来源：

ACS APPLIED MATERIALS & INTERFACES | 2023年 / 15卷 / 28期

关键词：

upconversion nanoparticles; titanium dioxide; gold nanorods; photodynamic therapy; photothermaltherapy; chemotherapy; PHOTODYNAMIC THERAPY; PHOTOTHERMAL THERAPY; GOLD NANORODS; TIO2; ABLATION; PLASMON; NANOMATERIALS; NANOPLATFORM; COMBINATION; RELEASE;

D O I：

10.1021/acsami.3c04300

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

This study prepared dumbbell-shaped titanium dioxide(TiO2)/gold nanorods (AuNRs) coated with mesoporous silicashells (mS)(AuNRs-TiO2@mS). Methotrexate (MTX) was further loadedinto the AuNRs-TiO2@mS, and then upconversion nanoparticles(UCNPs) were decorated to form AuNRs-TiO2@mS-MTX: UCNPnanocomposites. TiO2 is used as an intense photosensitizer(PS) to produce cytotoxic reactive oxygen species (ROS), leading tophotodynamic therapy (PDT). Concurrently, AuNRs exhibited intensephotothermal therapy (PTT) effects and photothermal conversion efficiency. In vitro results suggested that these nanocompositescan kill oral cancer cells (HSC-3) without toxicity through irradiationof NIR laser, owing to the synergistic effect. The in vivo studies indicated that these nanocomposites exhibited excellentantitumor effects through synergistic PDT/PTT/chemotherapy under anear-infrared (NIR) 808 nm laser irradiation. Thus, these AuNRs-TiO2@mS: UCNP nanocomposites have great potential to undergo deeptissue penetration with enhanced synergistic effects through NIR-triggeredlight for cancer treatment.

引用

页码：33335 / 33347

页数：13

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