Palladium-Catalyzed Multicomponent Cascade Reaction of 3-Hydroxypropionitrile: Synthesis of Substituted Dihydrochalcones

被引：5

作者：

Zheng, Jinming ^{[1
]}

Wang, Qingzong ^{[2
]}

Li, Yifei ^{[1
]}

Zheng, Huixian ^{[1
]}

Hu, Chaoyi ^{[1
]}

Hu, Xiaodong ^{[1
]}

Ye, Xiaoxia ^{[1
]}

Chen, Jiuxi ^{[2
]}

Li, Renhao ^{[1
]}

机构：

[1] Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Peoples R China

[2] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 13期

基金：

中国国家自然科学基金;

关键词：

CHEMOSELECTIVE HYDROGENATION; SELECTIVE SYNTHESIS; ARYLBORONIC ACIDS; ALPHA-ALKYLATION; KETONES; ALDEHYDES; ALCOHOLS; ANTIOXIDANT; DERIVATIVES; INHIBITORS;

D O I：

10.1021/acs.joc.3c00769

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Directaccess to substituted dihydrochalcones from the easily availablestarting materials 3-hydroxypropionitrile derivatives and arylboronicacids is described. The procedure involves a multicomponent aryl addition/hydroxylelimination/reduction Heck approach in the presence of a Pd catalystwith excellent functional group tolerance and a wide range of substrates.In addition, mixed 1,3-diarylation of 3-hydroxypropanenitrile usingtwo arylboronic acids with different electronic properties was alsoachieved.

引用

页码：9187 / 9198

页数：12

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