Fathoming the Role of mTOR in Diabetes Mellitus and its Complications

被引：5

作者：

Faheem ^{[1
]}

Sivasubrmanian, Shanthi ^{[2
]}

机构：

[1] Birla Inst Technol & Sci Pilani, Dept Pharm, Pilani Campus, Pilani 333031, Rajasthan, India

[2] Sri Ramachandra Inst Higher Educ & Res DU, Sri Ramachandra Fac Pharm, Dept Pharmacognosy, Chennai 600116, Tamil Nadu, India

来源：

CURRENT MOLECULAR PHARMACOLOGY | 2023年 / 16卷 / 05期

关键词：

mTOR; diabetes mellitus; insulin resistance; apoptosis; diabetic cardiomyopathy; diabetic nephropathy; diabetic retinopathy; BETA-CELL MASS; DIET-INDUCED OBESITY; MAMMALIAN TARGET; SIGNALING PATHWAY; HIGH GLUCOSE; COMPLEX; RAPAMYCIN; AUTOPHAGY; NEPHROPATHY; PHOSPHORYLATION;

D O I：

10.2174/1874467215666221005123919

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mechanistic/Mammalian target of rapamycin (mTOR) orchestrates cellular homeostasis by controlling cell growth, proliferation, metabolism, and survival by integrating various growth factors, nutrients and amino acids. Eccentric synchronization of mTOR has been incriminated in various diseases/disorders like cancer, neurodegenerative disorders, and diabetes mellitus and its complications. Recent reports also highlight the role of mTOR in diabetes and its associated complications. This review tries to fathom the role of mTOR signaling in diabetes mellitus and its complications- diabetic cardiomyopathy, diabetic nephropathy, and diabetic retinopathy and highlights mTOR as a putative target for the development of novel anti-diabetic drug candidates.

引用

页码：520 / 529

页数：10

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