Ginger essential oil and citral ameliorates atherosclerosis in ApoE-/- mice by modulating trimethylamine-N-oxide and gut microbiota

被引：9

作者：

Panyod, Suraphan ^{[1
,2
]}

Wu, Wei-Kai ^{[3
,4
]}

Peng, Sin-Yi ^{[1
]}

Tseng, Yea-Jing ^{[1
]}

Hsieh, Ya-Chi ^{[1
]}

Chen, Rou-An ^{[1
]}

Huang, Huai-Syuan ^{[1
]}

Chen, Yi-Hsun ^{[4
]}

Chuang, Hsiao-Li ^{[5
]}

Hsu, Cheng-Chih ^{[6
]}

Shen, Ting-Chin David ^{[7
]}

Yang, Kai-Chien ^{[8
,9
]}

Ho, Chi-Tang ^{[9
]}

Wu, Ming-Shiang ^{[4
,10
]}

Sheen, Lee-Yan ^{[1
,2
,11
,12
]}

机构：

[1] Natl Taiwan Univ, Inst Food Sci & Technol, Taipei, Taiwan

[2] Natl Taiwan Univ, Ctr Food & Biomol, Taipei, Taiwan

[3] Natl Taiwan Univ Hosp, Dept Med Res, Taipei, Taiwan

[4] Natl Taiwan Univ, Coll Med, Dept Internal Med, Taipei, Taiwan

[5] Natl Appl Res Labs, Natl Lab Anim Ctr, Taipei, Taiwan

[6] Natl Taiwan Univ, Dept Chem, Taipei, Taiwan

[7] Univ Penn, Perelman Sch Med, Div Gastroenterol, Pennsylvania, PA USA

[8] Natl Taiwan Univ, Dept & Grad Inst Pharmacol, Coll Med, Taipei, Taiwan

[9] Rutgers State Univ, Dept Food Sci, Coll Med, New Brunswick, NJ USA

[10] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan

[11] Natl Taiwan Univ, Natl Ctr Food Safety Educ & Res, Taipei, Taiwan

[12] Natl Taiwan Univ, Natl Ctr Food Safety Educ & Res, Taipei, Taiwan

来源：

NPJ SCIENCE OF FOOD | 2023年 / 7卷 / 01期

关键词：

CARDIOVASCULAR-DISEASE; MOUSE MODEL; CHOLESTEROL; METABOLISM; PLASMA;

D O I：

10.1038/s41538-023-00196-0

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Recently, the role of the gut microbiota in diseases, including cardiovascular disease (CVD), has gained considerable research attention. Trimethylamine-N-oxide (TMAO), which is formed during (sic)-carnitine metabolism, promotes the formation of atherosclerotic plaques, causing thrombosis. Here, we elucidated the anti-atherosclerotic effect and mechanism of ginger (Zingiber officinale Roscoe) essential oil (GEO) and its bioactive compound citral in Gubra Amylin NASH (GAN) diet with (sic)-carnitine-induced atherosclerosis female ApoE(-/-) mice. Treatment with GEO at both low and high doses and citral inhibited the formation of aortic atherosclerotic lesions, improved plasma lipid profile, reduced blood sugar, improved insulin resistance, decreased plasma TMAO levels, and inhibited plasma inflammatory cytokines, especially interleukin-1 beta. Additionally, GEO and citral treatment modulated gut microbiota diversity and composition by increasing the abundance of beneficial microbes and decreasing the abundance of CVD-related microbes. Overall, these results showed that GEO and citral may serve as potential dietary supplements for CVD prevention by improving gut microbiota dysbiosis.

引用

页数：10

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