Stimuli-responsive hydrogels for cancer immunotherapy

被引：10

作者：

Qin, Jinlong ^{[1
,2
]}

Sun, Min ^{[3
]}

Hu, Wei ^{[1
]}

Cheng, Jiajing ^{[2
]}

Fan, Zhen ^{[1
]}

Du, Jianzhong ^{[1
,2
,3
]}

机构：

[1] Tongji Univ, Sch Mat Sci & Engn, Dept Polymer Mat, 4800 Caoan Rd, Shanghai 201804, Peoples R China

[2] Tongji Univ, Shanghai Peoples Hosp 4, Sch Med, Dept Gynaecol & Obstet, Shanghai 200434, Peoples R China

[3] Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Orthoped, Shanghai 200072, Peoples R China

来源：

POLYMER CHEMISTRY | 2023年 / 14卷 / 07期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

CONTROLLED-RELEASE; DELIVERY; VACCINE; DESIGN; NANOPARTICLES; MECHANISMS; CELLS;

D O I：

10.1039/d2py01308h

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Immunotherapy plays an important role in cancer treatment by activating or suppressing the immune system. However, there are still a series of challenges to overcome regarding the delivery vehicles of immunotherapeutic agents and their effective activation at tumor sites. Meanwhile, owing to their well-hydrated environment and capability of immobilizing biological cargos, hydrogels in combination with immunotherapies provide a chance to enhance the antitumor immune response with reduced side effects. In addition, stimuli-responsiveness has been also widely applied to optimize the pharmacokinetics with an improved therapeutic outcome. In this review, we discuss the opportunities for the combination of immunotherapy and stimuli-responsive hydrogels, such as light, temperature, ultrasound and magnetically responsive hydrogels, for effective cancer treatment. Finally, we explore the potential of stimuli-responsive hydrogels as vaccine implants against cancer and Covid-19.

引用

页码：793 / 802

页数：10

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