The Relationship between the Oral Microbiota and Metabolic Syndrome

被引：9

作者：

Prince, Yvonne ^{[1
]}

Davison, Glenda M. ^{[1
]}

Davids, Saarah F. G. ^{[1
]}

Erasmus, Rajiv T. ^{[2
]}

Kengne, Andre P. ^{[3
]}

Graham, Lisa M. ^{[1
]}

Raghubeer, Shanel ^{[1
]}

Matsha, Tandi E. ^{[1
,4
]}

机构：

[1] Cape Peninsula Univ Technol, Fac Hlth & Wellness Sci, Dept Biomed Sci, SAMRC,CPUT,Cardiometab Hlth Res Unit, ZA-7530 Bellville, South Africa

[2] Stellenbosch Univ, Fac Med & Hlth Sci, Dept Pathol, ZA-7505 Cape Town, South Africa

[3] South African Med Res Council, Noncommunicable Dis Res Unit, ZA-7505 Cape Town, South Africa

[4] Sefako Makgatho Hlth Sci Univ, ZA-0208 Ga Rankuwa, South Africa

来源：

BIOMEDICINES | 2023年 / 11卷 / 01期

基金：

新加坡国家研究基金会; 英国医学研究理事会;

关键词：

metabolic syndrome; oral microbiota; subgingival plaque; rDNA; South Africa; diabetes; cardiovascular disease; FUSOBACTERIUM-NUCLEATUM; PERIODONTAL-DISEASE; EPITHELIAL-CELLS; CORONARY-HEART; HEALTH; MICROFLORA; SALIVA; RISK;

D O I：

10.3390/biomedicines11010003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The oral microbiota plays a crucial role in both systemic inflammation and metabolic syndrome (MetS), which is characterised by low-grade inflammation. Studies have analysed the gut microbiota using stool specimens from subjects with MetS; however, the etiological role of the oral microbiota in the development of MetS is still uncertain. We investigated the oral microbiota of 128 subgingival plaque samples from a South African cohort with and without MetS. After a comprehensive analysis of the oral microbiota, we observed a significant increase in Gram-positive aerobic and anaerobic microbiota in those with MetS. We observed an abundance of Actinomyces, Corynebacterium, and Fusobacterium genera in the MetS group, which differed significantly from previous studies, which found Granulicatella to be enriched in MetS. To further assess the impact of the metabolic parameters (FBG, Waist C, HDL, TGs, and BP) on the oral microbiota, we calculated the odds ratio (ORs) for significant oral microbiota identified between the MetS groups. We found that different species were associated with at least four MetS risk factors. This study has shown that the oral microbiota is disrupted in MetS and may promote inflammation providing a gateway to other systemic diseases, including diabetes and cardiovascular diseases.

引用

页数：12

共 36 条

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