COVID-19-Associated Pulmonary Aspergillosis in Intensive Care Unit Patients from Poland

被引：6

作者：

Skora, Magdalena ^{[1
]}

Gajda, Mateusz ^{[1
]}

Namysl, Magdalena ^{[2
]}

Wordliczek, Jerzy ^{[3
]}

Zorska, Joanna ^{[4
,5
]}

Piekielko, Piotr ^{[6
,7
]}

Zoltowska, Barbara ^{[8
]}

Krzysciak, Pawel ^{[1
]}

Heczko, Piotr B. ^{[1
]}

Wojkowska-Mach, Jadwiga ^{[1
]}

机构：

[1] Jagiellonian Univ, Fac Med, Chair Microbiol, Med Coll, Czysta 18 St, PL-31121 Krakow, Poland

[2] Univ Hosp Krakow, Dept Microbiol, Macieja Jakubowskiego 2 St, PL-30688 Krakow, Poland

[3] Jagiellonian Univ, Interdisciplinary Intens Care Clin, Med Coll, Macieja Jakubowskiego 2 St, PL-30688 Krakow, Poland

[4] Jagiellonian Univ, Ctr Innovat Med Educ, Med Coll, Med 7 St, PL-30688 Krakow, Poland

[5] Univ Hosp Krakow, Care Unit 5Intens, Macieja Jakubowskiego 2 St, PL-30688 Krakow, Poland

[6] Ctr Pulmonol & Thorac Surg Bystra, Dept Internal Dis & Circulatory Failure, Juliana Falata 2 St, PL-43360 Bystra, Poland

[7] Ctr Pulmonol & Thorac Surg Bystra, Dept Pulmonol & Resp Failure, Juliana Falata 2 St, PL-43360 Bystra, Poland

[8] Univ Hosp Krakow, Ctr Innovat Therapy, Clin Res Coordinat Ctr, Macieja Jakubowskiego 2 St, PL-30688 Krakow, Poland

来源：

JOURNAL OF FUNGI | 2023年 / 9卷 / 06期

关键词：

Aspergillus; COVID-associated pulmonary aspergillosis; CAPA; invasive aspergillosis; SARS-CoV-2; CRITICALLY-ILL PATIENTS; COVID-19; DIAGNOSIS; EPIDEMIOLOGY; MANAGEMENT;

D O I：

10.3390/jof9060666

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Coronavirus disease 2019 (COVID-19) has been shown to be a favoring factor for aspergillosis, especially in a severe course requiring admission to the intensive care unit (ICU). The aim of the study was to assess the morbidity of CAPA among ICU patients in Poland and to analyze applied diagnostic and therapeutic procedures. Medical documentation of patients hospitalized at the temporary COVID-19 dedicated ICU of the University Hospital in Krakow, Poland, from May 2021 to January 2022 was analyzed. In the analyzed period, 17 cases of CAPA were reported with an incidence density rate of 9 per 10 000 patient days and an incidence rate of 1%. Aspergillus fumigatus and Aspergillus niger were isolated from lower respiratory samples. Antifungal therapy was administered to 9 patients (52.9%). Seven patients (77.8%) received voriconazole. The CAPA fatality case rate was 76.5%. The results of the study indicate the need to increase the awareness of medical staff about the possibility of fungal co-infections in ICU patients with COVID-19 and to use the available diagnostic and therapeutic tools more effectively.

引用

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