An optimized radiosynthesis of [18F]DK222, a PET radiotracer for imaging PD-L1

被引：3
作者：
Holt, Daniel P. [1 ]
Kumar, Dhiraj [1 ]
Nimmagadda, Sridhar [1 ]
Dannals, Robert F. [1 ,2 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Radiol, Div Nucl Med & Mol Imaging, Baltimore, MD USA
[2] Johns Hopkins Univ, Sch Med, Dept Radiol, Div Nucl Med & Mol Imaging, 600 North Wolfe St, Nelson B1-152, Baltimore, MD 21287 USA
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2023年 / 66卷 / 02期
基金：
美国国家卫生研究院;
关键词：
AlF; fluorine-18; PD-L1; PET; radiochemistry; STABILITY;
D O I：
10.1002/jlcr.4012
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A radiochemical synthesis of [F-18]DK222, a peptide binder of programmed death ligand 1 protein, suitable for human PET studies is described, and results from validation productions are presented. The high specific activity radiotracer product is prepared as a sterile, apyrogenic solution that conforms to current Good Manufacturing Practice (cGMP) requirements. In addition, the production is extended to use a commercial synthesizer platform (General Electric FASTlab 2).
引用
收藏
页码：47 / 54
页数：8
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