An optimized radiosynthesis of [18F]DK222, a PET radiotracer for imaging PD-L1

被引：3

作者：

Holt, Daniel P. ^{[1
]}

Kumar, Dhiraj ^{[1
]}

Nimmagadda, Sridhar ^{[1
]}

Dannals, Robert F. ^{[1
,2
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Radiol, Div Nucl Med & Mol Imaging, Baltimore, MD USA

[2] Johns Hopkins Univ, Sch Med, Dept Radiol, Div Nucl Med & Mol Imaging, 600 North Wolfe St, Nelson B1-152, Baltimore, MD 21287 USA

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2023年 / 66卷 / 02期

基金：

美国国家卫生研究院;

关键词：

AlF; fluorine-18; PD-L1; PET; radiochemistry; STABILITY;

D O I：

10.1002/jlcr.4012

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A radiochemical synthesis of [F-18]DK222, a peptide binder of programmed death ligand 1 protein, suitable for human PET studies is described, and results from validation productions are presented. The high specific activity radiotracer product is prepared as a sterile, apyrogenic solution that conforms to current Good Manufacturing Practice (cGMP) requirements. In addition, the production is extended to use a commercial synthesizer platform (General Electric FASTlab 2).

引用

页码：47 / 54

页数：8

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