From synergy to resistance: Navigating the complex relationship between sorafenib and ferroptosis in hepatocellular carcinoma

被引：28
作者：
Wang, Zijian [1 ]
Zhou, Chunyang [2 ]
Zhang, Yiming [3 ]
Tian, Xinchen [3 ]
Wang, Haochen [3 ]
Wu, Jibiao [1 ]
Jiang, Shulong [3 ,4 ]
机构：
[1] Shandong Univ Tradit Chinese Med, Coll Tradit Chinese Med, Jinan, Peoples R China
[2] Shandong Univ, Qilu Hosp Qingdao, Cheeloo Coll Med, Dept Radiat Oncol, Qingdao, Peoples R China
[3] Shandong First Med Univ, Jining Peoples Hosp 1, Clin Med Lab Ctr, Jining, Shandong, Peoples R China
[4] Shandong Univ Tradit Chinese Med, Coll Clin Med 1, Jinan, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2024年 / 170卷
基金：
中国国家自然科学基金;
关键词：
Ferroptosis; Sorafenib; Hepatocellular carcinoma; Dualistic role; NRF2; CELL-DEATH; PHASE-III; LIVER-CANCER; PROMOTES FERROPTOSIS; RAF/MEK/ERK PATHWAY; LIPID-METABOLISM; IN-VITRO; IRON; MECHANISMS; TRIAL;
D O I：
10.1016/j.biopha.2023.116074
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Hepatocellular carcinoma (HCC) remains a major global health burden, and sorafenib, a multi-kinase inhibitor, has shown effectiveness in the treatment of HCC and is considered as the first-line therapy for advanced HCC. However, the response to sorafenib varies among patients, and the development of drug resistance poses a prevalent obstacle. Ferroptosis, a newly characterized form of cell death featured by iron-dependent lipid per -oxidation, has emerged as a critical player in the reaction to sorafenib therapy in HCC. The induction of fer-roptosis has been shown to augment the anticancer benefits of sorafenib. However, it has also been observed to contribute to sorafenib resistance. This review presents a comprehensive and thorough analysis that elucidates the intricate relationship between ferroptosis and sorafenib over recent years, aiming to formulate effective therapeutic approaches for liver cancer. Based on this exploration, we propose innovative strategies intended to overcome sorafenib resistance via targeted modulation of ferroptosis.
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页数：15
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