Insights into the molecular mechanisms and signalling pathways of epithelial to mesenchymal transition (EMT) in colorectal cancer: A systematic review and bioinformatic analysis of gene expression

被引：5

作者：

Azizan, Suha ^{[1
]}

Cheng, Kim Jun ^{[1
]}

Mohamed, Elsa Haniffah Mejia ^{[1
]}

Ibrahim, Kamariah ^{[2
]}

Faruqu, Farid Nazer ^{[1
]}

Vellasamy, Kumutha Malar ^{[3
]}

Khong, Tak Loon ^{[4
]}

Syafruddin, Saiful Effendi ^{[5
]}

Ibrahim, Zaridatul Aini ^{[1
]}

机构：

[1] Univ Malaya, Fac Med, Dept Pharmacol, Kuala Lumpur 50603, Malaysia

[2] Univ Malaya, Fac Med, Dept Biomed Sci, Kuala Lumpur 50603, Malaysia

[3] Univ Malaya, Fac Med, Dept Med Microbiol, Kuala Lumpur 50603, Malaysia

[4] Univ Malaya, Fac Med, Dept Surg, Kuala Lumpur 50603, Malaysia

[5] UKM Med Ctr, UKM Med Mol Biol Inst UMBI, Kuala Lumpur 56000, Malaysia

来源：

GENE | 2024年 / 896卷

关键词：

Colorectal cancer; Gene expression; Epithelial to mesenchymal transition; Bioinformatic analysis; Systematic review; Differentially expressed genes; VASOACTIVE-INTESTINAL-PEPTIDE; 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE; C-KIT; PROGRESSION; CELLS; CHEMOKINES; MIGRATION; PI3K/AKT; INVASION; GROWTH;

D O I：

10.1016/j.gene.2023.148057

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Colorectal cancer (CRC) is ranked as the second leading cause of mortality worldwide, mainly due to metastasis. Epithelial to mesenchymal transition (EMT) is a complex cellular process that drives CRC metastasis, regulated by changes in EMT-associated gene expression. However, while numerous genes have been identified as EMT regulators through various in vivo and in vitro studies, little is known about the genes that are differentially expressed in CRC tumour tissue and their signalling pathway in regulating EMT. Using an integration of sys-tematic search and bioinformatic analysis, gene expression profiles of CRC tumour tissues were compared to non-tumour adjacent tissues to identify differentially expressed genes (DEGs), followed by performing systematic review on common identified DEGs. Fifty-eight common DEGs were identified from the analysis of 82 tumour tissue samples obtained from four gene expression datasets (NCBI GEO). These DEGS were then systematically searched for their roles in modulating EMT in CRC based on previously published studies. Following this, 10 common DEGs (CXCL1, CXCL8, MMP1, MMP3, MMP7, TACSTD2, VIP, HPGD, ABCG2, CLCA4) were included in this study and subsequently subjected to further bioinformatic analysis. Their roles and functions in modulating EMT in CRC were discussed in this review. This study enhances our understanding of the molecular mechanisms underlying EMT and uncovers potential candidate genes and pathways that could be targeted in CRC.

引用

页数：14

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