Ga3+ loaded radiation crosslinked gel-Alg-CMC hydrogels for promoting diabetic wound healing

被引：5

作者：

Chen, Gong ^{[1
]}

Ren, Kang ^{[1
]}

Wang, Hongjian ^{[1
]}

Wu, Lihao ^{[1
]}

Wang, Dai ^{[1
]}

Xu, Ling ^{[1
,2
]}

机构：

[1] Xiamen Univ, Sch Publ Hlth, Dept Lab Med, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen 361102, Peoples R China

[2] Xiamen Univ, Shenzhen Res Inst, Shenzhen 518000, Peoples R China

来源：

JOURNAL OF BIOMATERIALS APPLICATIONS | 2023年 / 37卷 / 09期

关键词：

Hydrogel; radiation cross-linked; antibacterial; wound healing; ANTIBACTERIAL;

D O I：

10.1177/08853282231151375

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The metal gallium holds great promise in the fight against infection by disrupting bacterial iron metabolism through a "Trojan horse" technique. It is well worth trying to investigate the potential for gallium-mediated hydrogels for the treatment of infected wounds. In this paper, Ga3+ is innovatively given an important role in hydrogels based on the conventional multi-component hydrogel with metal ion binding gelation strategy. Thus, Ga@Gel-Alg-CMCs hydrogel with broad-spectrum antimicrobial activity is reported on the treatment of infected wounds. The morphology, degradability, and swelling behavior together indicated the excellent physical properties of this hydrogel. Interestingly, in vivo results also showed favorable biocompatibility, slowing down wound infection and promoting diabetic wound healing, making the gallium-doped hydrogel an ideal antimicrobial dressing.

引用

页码：1676 / 1686

页数：11

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