Sex differences in CD8+ T cell responses during adaptive immunity

被引：2
|
作者：
Layug, Paul Jerard [1 ,2 ]
Vats, Harman [2 ,3 ]
Kannan, Kamali [2 ,4 ]
Arsenio, Janilyn [1 ,2 ,3 ,4 ]
机构：
[1] Univ Manitoba, Max Rady Coll Med, Dept Internal Med, Winnipeg, MB, Canada
[2] Univ Manitoba, Manitoba Ctr Prote & Syst Biol, Winnipeg, MB, Canada
[3] Univ Manitoba, Max Rady Coll Med, Winnipeg, MB, Canada
[4] Univ Manitoba, Max Rady Coll Med, Rady Fac Hlth Sci, Winnipeg, MB, Canada
来源：
WIRES MECHANISMS OF DISEASE | 2024年 / 16卷 / 05期
关键词：
autoimmunity; cancer; CD8+T cell; exhaustion; infection; sex bias; T cell immunity; LYMPHOCYTE SUBSETS; X-CHROMOSOME; EFFECTOR; EXHAUSTION; AGE; DIFFERENTIATION; FEMALES; CANCER; SUSCEPTIBILITY; EXPRESSION;
D O I：
10.1002/wsbm.1645
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Biological sex is an important variable that influences the immune system's susceptibility to infectious and non-infectious diseases and their outcomes. Sex dimorphic features in innate and adaptive immune cells and their activities may help to explain sex differences in immune responses. T lymphocytes in the adaptive immune system are essential to providing protection against infectious and chronic inflammatory diseases. In this review, T cell responses are discussed with focus on the current knowledge of biological sex differences in CD8(+) T cell mediated adaptive immune responses in infectious and chronic inflammatory diseases. Future directions aimed at investigating the molecular and cellular mechanisms underlying sex differences in diverse T cell responses will continue to underscore the significance of understanding sex differences in protective immunity at the cellular level, to induce appropriate T cell-based immune responses in infection, autoimmunity, and cancer. This article is categorized under: Immune System Diseases > Molecular and Cellular Physiology Infectious Diseases > Molecular and Cellular Physiology
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页数：13
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