Mucosal damage in pancreaticobiliary maljunction is stronger in the gallbladder than in the bile duct

被引：3

作者：

Kamakura, Masato ^{[1
]}

Uehara, Takeshi ^{[2
,7
]}

Muraki, Takashi ^{[3
]}

Iwaya, Mai ^{[2
]}

Asaka, Shiho ^{[2
,4
]}

Nakajima, Tomoyuki ^{[2
]}

Iwaya, Yugo ^{[1
]}

Nagaya, Tadanobu ^{[1
]}

Yoshizawa, Takahiro ^{[5
]}

Shimizu, Akira ^{[5
]}

Kuraishi, Yasuhiro ^{[1
]}

Ota, Hiroyoshi ^{[2
,6
]}

Umemura, Takeji ^{[1
]}

机构：

[1] Shinshu Univ, Sch Med, Dept Med, Div Gastroenterol & Hepatol, Matsumoto, Japan

[2] Shinshu Univ, Sch Med, Dept Lab Med, Matsumoto, Japan

[3] Azumi Hosp, North Alps Med Ctr, Dept Gastroenterol, Ikeda, Japan

[4] Nagano Childrens Hosp, Dept Lab Med, Azumino, Japan

[5] Shinshu Univ, Sch Med, Dept Surg, Div Gastroenterol Hepatobiliary Pancreat Transplan, Matsumoto, Japan

[6] Shinshu Univ, Sch Med, Dept Biomed Lab Med, Matsumoto, Japan

[7] Shinshu Univ, Sch Med, Dept Lab Med, 3-1-1 Asahi, Matsumoto, Nagano 3908621, Japan

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2024年 / 253卷

关键词：

Pancreaticobiliary maljunction; Carcinogenesis; gamma H2AX; DNA damage; Gallbladder; Bile duct; BILIARY; CARCINOGENESIS; H2AX;

D O I：

10.1016/j.prp.2023.155011

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Background: The frequency of gallbladder carcinoma is high in pancreaticobiliary maljunction (PBM), and the mechanism of carcinogenesis is not well understood.Methods: The expression of gamma H2AX, the most sensitive marker for detecting DNA damage, was analyzed using immunohistochemistry in patients with PBM, in which the gallbladder and bile duct were simultaneously resected. Gallbladder and bile ducts were evaluated in non-neoplastic regions in 13 cases of PBM without cancer in the gallbladder and bile ducts.Results: The median frequencies of gamma H2AX expression in the bile duct and gallbladder within the same case were 5.9% (range 1.7-12.05%) and 9.9% (range 2.8-25%), respectively, and were significantly higher in the gallbladder mucosa (P < 0.0004). gamma H2AX expression strongly correlated in the bile duct and gallbladder (r = 0.9436, P < 0.0001). PBM caused marked mucosal damage to the gallbladder.Conclusions: Mucosal damage may be involved in carcinogenesis, which may be useful for predicting malignant transformation.

引用

页数：5

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