The prognostic value of lymph node ratio for thyroid cancer: a meta-analysis

被引:4
作者
Hu, Yue [1 ]
Wang, Zhiyi [1 ]
Dong, Lishuo [2 ]
Zhang, Lu [3 ]
Li, Xiuyang [4 ]
机构
[1] Beijing Univ Chinese Med, Qi Huang Chinese Med, Beijing, Peoples R China
[2] Changchun Univ Chinese Med, Coll Tradit Chinese Med, Changchun, Peoples R China
[3] Hosp Chengdu Univ Tradit Chinese Med, Dept Endocrinol, Chengdu, Peoples R China
[4] China Acad Chinese Med Sci, Guanganmen Hosp, Beijing, Peoples R China
关键词
thyroid cancer; meta-analysis; prognosis; lymph node ratio; disease-free survival; MANAGEMENT;
D O I
10.3389/fonc.2024.1333094
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background The prognostic value of lymph node ratio (LNR) has been proved in several cancers. However, the potential of LNR to be a prognostic factor for thyroid cancer has not been validated so far. This article evaluated the prognostic value of LNR for thyroid cancer through a meta-analysis. Methods A systematic search was conducted for eligible publications that study the prognostic values of LNR for thyroid cancer in the databases of PubMed, EMBASE, Cochrane, and Web of Science up until October 24, 2023. The quality of the eligible studies was evaluated by The Newcastle-Ottawa Assessment Scale of Cohort Study. The effect measure for meta-analysis was Hazard Ratio (HR). Random effect model was used to calculate the pooled HR and 95% confidence intervals. A sensitivity analysis was applied to assess the stability of the results. Subgroup analysis and a meta-regression were performed to explore the source of heterogeneity. And a funnel plot, Begg's and Egger's tests were used to evaluate publication bias. Results A total of 15,698 patients with thyroid cancer from 24 eligible studies whose quality were relatively high were included. The pooled HR was 4.74 (95% CI:3.67-6.11; P<0.05) and a moderate heterogeneity was shown (I2 = 40.8%). The results of meta-analysis were stable according to the sensitivity analysis. Similar outcome were shown in subgroup analysis that higher LNR was associated with poorer disease-free survival (DFS). Results from meta-regression indicated that a combination of 5 factors including country, treatment, type of thyroid cancer, year and whether studies control factors in design or analysis were the origin of heterogeneity. Conclusion Higher LNR was correlated to poorer disease free survival in thyroid cancer. LNR could be a potential prognostic indicator for thyroid cancer. More effort should be made to assess the potential of LNR to be included in the risk stratification systems for thyroid cancer. Systematic review registration https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=477135, identifier CRD42023477135.
引用
收藏
页数:12
相关论文
共 40 条
[1]   Thyroid Cancer Incidence Patterns in the United States by Histologic Type, 1992-2006 [J].
Aschebrook-Kilfoy, Briseis ;
Ward, Mary H. ;
Sabra, Mona M. ;
Devesa, Susan S. .
THYROID, 2011, 21 (02) :125-134
[2]   Thyroid cancer [J].
Cabanillas, Maria E. ;
McFadden, David G. ;
Durante, Cosimo .
LANCET, 2016, 388 (10061) :2783-2795
[3]   Thyroid cancer [J].
Chen, Debbie W. ;
Lang, Brian H. H. ;
McLeod, Donald S. A. ;
Newbold, Kate ;
Haymart, Megan R. .
LANCET, 2023, 401 (10387) :1531-1544
[4]   Follicular cell-derived thyroid cancer [J].
Dralle, Henning ;
Machens, Andreas ;
Basa, Johanna ;
Fatourechi, Vahab ;
Franceschi, Silvia ;
Hay, Ian D. ;
Nikiforov, Yuri E. ;
Pacini, Furio ;
Pasieka, Janice L. ;
Sherman, Steven I. .
NATURE REVIEWS DISEASE PRIMERS, 2015, 1
[5]   Sorafenib and Thyroid Cancer [J].
Fallahi, Poupak ;
Ferrari, Silvia Martina ;
Santini, Francesca ;
Corrado, Alda ;
Materazzi, Gabriele ;
Ulisse, Salvatore ;
Miccoli, Paolo ;
Antonelli, Alessandro .
BIODRUGS, 2013, 27 (06) :615-628
[6]   Number of Positive Lymph Nodes Is Superior to LNR and LODDS for Predicting the Prognosis of Pancreatic Neuroendocrine Neoplasms [J].
Gao, Bingqiang ;
Zhou, Dongkai ;
Qian, Xiaohui ;
Jiang, Yuancong ;
Liu, Zhenghao ;
Zhang, Wang ;
Wang, Weilin .
FRONTIERS IN ENDOCRINOLOGY, 2021, 12
[7]   Risk Factors for Recurrence of Follicular Thyroid Cancer: A Systematic Review [J].
Gronlund, Mathias Peter ;
Jensen, Jakob Schmidt ;
Hahn, Christoffer Holst ;
Gronhoj, Christian ;
von Buchwald, Christian .
THYROID, 2021, 31 (10) :1523-1530
[8]   Enhanced secondary analysis of survival data: reconstructing the data from published Kaplan-Meier survival curves [J].
Guyot, Patricia ;
Ades, A. E. ;
Ouwens, Mario J. N. M. ;
Welton, Nicky J. .
BMC MEDICAL RESEARCH METHODOLOGY, 2012, 12
[9]   2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer [J].
Haugen, Bryan R. ;
Alexander, Erik K. ;
Bible, Keith C. ;
Doherty, Gerard M. ;
Mandel, Susan J. ;
Nikiforov, Yuri E. ;
Pacini, Furio ;
Randolph, Gregory W. ;
Sawka, Anna M. ;
Schlumberger, Martin ;
Schuff, Kathryn G. ;
Sherman, Steven I. ;
Sosa, Julie Ann ;
Steward, David L. ;
Tuttle, R. Michael ;
Wartofsky, Leonard .
THYROID, 2016, 26 (01) :1-133
[10]   Measuring inconsistency in meta-analyses [J].
Higgins, JPT ;
Thompson, SG ;
Deeks, JJ ;
Altman, DG .
BMJ-BRITISH MEDICAL JOURNAL, 2003, 327 (7414) :557-560