Ulcerative Colitis-associated Spondyloarthritis Successfully Treated with Infliximab in the Absence of Enhanced TNF-α Responses

被引：1

作者：

Fujita, Shunsuke ^{[1
]}

Honjo, Hajime ^{[1
]}

Takada, Ryutaro ^{[1
]}

Hara, Akane ^{[1
]}

Masuta, Yasuhiro ^{[1
]}

Otsuka, Yasuo ^{[1
]}

Handa, Kohei ^{[1
]}

Minaga, Kosuke ^{[1
]}

Tsuji, Shigeyoshi ^{[2
]}

Kudo, Masatoshi ^{[1
]}

Watanabe, Tomohiro ^{[1
]}

机构：

[1] Kindai Univ, Fac Med, Dept Gastroenterol & Hepatol, Higashiosaka, Japan

[2] Nippon Life Hosp, Dept Orthopaed Surg, Osaka, Japan

来源：

INTERNAL MEDICINE | 2023年 / 62卷 / 17期

基金：

日本学术振兴会;

关键词：

spondyloarthritis; ulcerative colitis; IL-6; TNF; infliximab; REGULATORY T-CELLS; ACTIVATION; APOPTOSIS; THERAPY; BINDING; NUMBER;

D O I：

10.2169/internalmedicine.1182-22

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Although concurrent occurrence of spondyloarthritis (SpA) and ulcerative colitis (UC) is sometimes seen, the profiles of cytokines have been poorly understood in UC-associated SpA. We herein report a case of UCassociated SpA successfully treated with infliximab (IFX). Profiles of cytokines in the serum and colonic mucosa were characterized by an enhanced expression of IL-6 but not tumor necrosis factor (TNF)-alpha. Successful induction of remission by IFX was associated with the downregulation of IL-6 expression but no significant alteration in TNF-alpha expression. These findings suggest that some cases of UC-associated SpA might be driven by IL-6, and IFX might be effective in cases lacking enhanced TNF-alpha responses.

引用

页码：2493 / 2497

页数：5

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