How to overcome barriers to the implementation of prevention and treatment strategies for atherosclerotic cardiovascular disease through lipid-lowering therapy

被引：0

作者：

Arca, Marcello ^{[1
]}

Averna, Maurizio ^{[2
,3
]}

Borghi, Claudio ^{[4
]}

Lettino, Maddalena ^{[5
]}

Filardi, Pasquale Perrone ^{[6
]}

Alberti, Antonia ^{[7
,8
]}

Bilato, Claudio ^{[9
]}

Calabro, Paolo ^{[10
,11
]}

Carubbi, Francesca ^{[12
]}

Ciccone, Marco Matteo ^{[13
]}

Cipollone, Francesco ^{[14
]}

Citroni, Nadia ^{[15
]}

De Luca, Leonardo ^{[16
]}

Giaccari, Andrea ^{[17
,18
]}

Iannuzzo, Gabriella ^{[19
]}

Maloberti, Alessandro ^{[20
,21
]}

Marcucci, Rossella ^{[22
]}

Spinazzola, Pasquale Pignatelli ^{[23
,24
]}

Pirro, Matteo ^{[25
]}

Pisciotta, Livia ^{[26
]}

Sarullo, Filippo ^{[27
]}

Sciacqua, Angela ^{[28
]}

Suppressa, Patrizia ^{[29
,30
]}

Varbella, Ferdinando ^{[31
,32
]}

Werba, Jose Pablo ^{[33
]}

Zambon, Alberto ^{[34
]}

机构：

[1] Sapienza Univ Roma, Dipartimento Med Traslaz & Precis, Rome, Italy

[2] Univ Palermo, Dipartimento Promoz Salute Cura Madre & Bambino, Med Interna & Special Med, Palermo, Italy

[3] Ctr Nazl Ric CNR, Ist Biofis, Palermo, Italy

[4] Univ Bologna, Dipartimento Sci Med & Chirurg, Dipartimento Med Cardiotorac, Policlin S Orsola Malpighi, Bologna, Italy

[5] Fdn IRCCS San Gerardo dei Tintori, Monza, Italy

[6] Univ Naples Federico II, Dipartimento Sci Biomed Avanzate, Naples, Italy

[7] ASST Grande Osped Metropolitano Niguarda, Dipartimento Cardiotoracovasc, SSD Diag & Cure Terr Malattie Cardiache, Milan, Italy

[8] ASST Grande Osped Metropolitano Niguarda, Ctr Clin Dislipidemie Grossi Paoletti, Dipartimento Cardiotoracovasc, Milan, Italy

[9] Osped Ovest Vicentino, UOC Cardiol, Arzignano, VI, Italy

[10] AORN St Anna & San Sebastiano, Cardiol Clin, Caserta, Italy

[11] Univ Campania Luigi Vanvitelli, Dipartimento Sci Med Traslaz, Naples, Italy

[12] Univ Modena & Reggio Emilia, Osped Baggiovara, Dipartimento Sci Biomed Metab & Neurosci, UO Med Metab,AOU Modena, Modena, Italy

[13] Policlin Univ, UO Cardiol, Bari, Italy

[14] Policlin SS Annunziata, Clin Med, Chieti, Italy

[15] Osped Trento, Ctr Dislipidemie & Aterosclerosi, APSS, Trento, Italy

[16] Azienda Osped San Camillo Forlanini, Dipartimento Sci Cardiotoracovasc, UOC Cardiol, Rome, Italy

[17] Univ Cattolica Sacro Cuore, Dipartimento Med Chirurg Traslaz, Rome, Italy

[18] Fdn Policlin Univ A Gemelli IRCCS, Ctr Malattie Endocrine Metab, Rome, Italy

[19] Univ Napoli Federico II, Dipartimento Med Clin & Chirurg, Naples, Italy

[20] ASST Grande Osped Metropolitano Niguarda, Ctr Cardiol A Gasperis, Fac Med, SC Cardiol 4, Milan, Italy

[21] Univ Milano Bicocca, Fac Med Chirurg, Milan, Italy

[22] Univ Firenze, Dipartimento Med Sperimentale & Clin, Florence, Italy

[23] Sapienza Univ Roma, Clin Med 1, Med Interna Covid, Rome, Italy

[24] Sapienza Univ Roma, Ctr Trombosi, Dipartimento Sci Clin Internist Anestesiol & Card, Rome, Italy

[25] Univ Perugia, Dipartimento Med & Chirurg, Perugia, Italy

[26] Univ Genoa, IRCCS Osped Policlin San Martino, Dipartimento Med Interna, Genoa, Italy

[27] Osped Buccheri Ferla Fatebenefratelli, UO Cardiol Riabilitat, Palermo, Italy

[28] Magna Graecia Univ Catanzaro, Dipartimento Sci Med & Chirurg, UOC Geriatria, AOU Mater Domini, Catanzaro, Italy

[29] Azienda Osped Univ Policlin Bari, Med Interna C Frugoni, Bari, Italy

[30] Azienda Osped Univ Policlin Bari, Ctr Sovraziendale Malattie Rare, Bari, Italy

[31] ASLTO3, Dipartimento Med, SC Cardiol, Rivoli, TO, Italy

[32] Azienda Osped Univ San Luigi, Orbassano, TO, Italy

[33] IRCCS, Ctr Cardiol Monzino, Unita Prevenz Aterosclerosi, Milano, TX USA

[34] Univ Padua, Dipartimento Med DIMED, Via Giustiniani 2, I-35128 Padua, Italy

来源：

GIORNALE ITALIANO DI CARDIOLOGIA | 2023年 / 24卷 / 10期

关键词：

Adherence; Atherosclerotic cardiovascular disease; Ezetimibe; Inclisiran; LDL-cholesterol; Lipid-lowering therapy; PCSK9; inhibitors; Persistence; Statins; MEDICATION ADHERENCE; LDL CHOLESTEROL; STATIN THERAPY; 000; PARTICIPANTS; INDIVIDUAL DATA; ADVERSE EVENTS; RISK; METAANALYSIS; EFFICACY; ASSOCIATION;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Atherosclerotic cardiovascular diseases remain the main cause of mortality worldwide, due to a poor control of modifiable risk factors for atherosclerosis. High levels of low-density lipoprotein cholesterol represent the most relevant actor in the development of atherosclerotic cardiovascular diseases, as well as the main target of prevention strategies. Although lipid-lowering treatments were shown to be effective for cardiovascular prevention, several barriers (e.g. clinician reluctance to prescribe an intensive treatment, poor adherence of patients to therapy, high pharmacotherapy burden of high-risk patients and the fear for adverse events potentially associated with statins) still prevent therapy optimization. Such issues will be addressed in this review article, taking into account possible strategies for their solution, through an integrated approach including both management interventions and a larger use of the available pharmacologic options.

引用

页码：770 / 780

页数：11

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