Unwinding the potentials of vitamin C in COVID-19 and other diseases: An updated review

被引:8
作者
Mehta, Nikhil [1 ]
Pokharna, Purvi [1 ]
Shetty, Saritha R. [1 ,2 ]
机构
[1] Shobhaben Pratapbhai Patel Sch Pharm & Technol Man, SVKMs NMIMS, Dept Pharmaceut, Mumbai, India
[2] Shobhaben Pratapbhai Patel Sch Pharm & Technol Man, SVKMs NMIMS, Dept Pharmaceut, Mumbai 400056, India
关键词
Vitamin C; scurvy; antioxidant; neurodegenerative; COVID-19; ASCORBIC-ACID THERAPY; NITRIC-OXIDE SYNTHASE; BRUSH-BORDER MEMBRANE; OXIDATIVE STRESS; DIETARY SUPPLEMENTATION; GLUCOSE-TRANSPORTER; OXALATE NEPHROPATHY; GENETIC-VARIATION; OXIDIZED LDL; RISK-FACTORS;
D O I
10.1177/02601060221139628
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: The discovery of vitamin C (ascorbic acid) is related to the ancient history of persistent research on the origins of the haemorrhagic disease scurvy. Vitamin C is an important nutrient that aids in a variety of biological and physiological processes. Scientists have been researching the function of vitamin C in the prevention and ailment of sepsis and pneumonia for decades. This has created a potential platform for applying these results to individuals suffering from severe coronavirus infection (COVID-19). Vitamin C's ability to activate and enhance the immune system makes it a promising treatment in the present COVID-19 pandemic. Vitamin C also aids in the activation of vitamin B, the production of certain neurotransmitters, and the transformation of cholesterol into bile acids. Hence, vitamin C is used for the treatment of many diseases. Aim: This review highlights the Vitamin C investigations that are performed by various researchers on patients with COVID 19 infection, the clinical studies and their observations. The authors have additionally updated information on the significance of vitamin C insufficiency, as well as its relevance and involvement in diseases such as cancer, wound healing, iron deficiency anaemia, atherosclerosis and neurodegenerative disorders. Here, we discuss them with the references. Methods: The method used in order to perform literature search was done using SciFinder, PubMed and ScienceDirect. Results: There is a potential role of vitamin C in various diseases including neurodegenerative disorders, COVID-19 and other diseases and the results are highlighted in the review with the help of clinical and preclinical data. Conclusion: More research on vitamin C and the undergoing clinical trials might prove a potential role of vitamin C in protecting the population from current COVID-19 pandemic.
引用
收藏
页码:415 / 433
页数:19
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