Perivascular spaces mediate a relationship between diabetes and other cerebral small vessel disease markers in cerebrovascular and neurodegenerative diseases

被引：6

作者：

Zebarth, Julia ^{[1
,2
]}

Kamal, Radia ^{[1
,2
]}

Perlman, George ^{[1
,2
]}

Ouk, Michael ^{[1
,2
]}

Xiong, Lisa Y. ^{[1
,2
]}

Yu, Di ^{[1
,2
]}

Lin, William Z. ^{[1
,2
]}

Ramirez, Joel ^{[1
]}

Masellis, Mario ^{[1
]}

Goubran, Maged ^{[1
,4
]}

MacIntosh, Bradley J. ^{[1
,4
]}

Black, Sandra E. ^{[1
]}

Cogo-Moreira, Hugo ^{[5
]}

Scott, Christopher J. M. ^{[1
]}

Bartha, Robert ^{[6
]}

Symons, Sean ^{[1
]}

Haddad, Seyyed M. H. ^{[7
]}

Ozzoude, Miracle ^{[1
]}

Nanayakkara, Nuwan ^{[8
]}

Beaton, Derek ^{[9
]}

Arnott, Stephen ^{[10
]}

Dowlatshahi, Dariush ^{[11
]}

Swartz, Richard H. ^{[1
]}

Saposnik, Gustavo ^{[12
]}

Grimes, David ^{[11
]}

Lang, Anthony ^{[14
,15
,16
]}

Fischer, Corinne E. ^{[17
]}

Frank, Andrew ^{[18
]}

Kumar, Sanjeev ^{[19
,20
]}

Pollock, Bruce G. ^{[2
,3
,20
]}

Tang-Wai, David ^{[14
,15
,21
]}

Finger, Elizabeth ^{[22
]}

Rabin, Jennifer S. ^{[1
,23
,24
,25
]}

Swardfager, Walter ^{[1
,2
,13
]}

机构：

[1] Sunnybrook Res Inst, Dr Sandra Black Ctr Brain Resilience & Recovery, Hurvitz Brain Sci Program, LC Campbell Cognit Neurol, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada

[2] Univ Toronto, Dept Pharmacol & Toxicol, Med Sci Bldg 1,Kings Coll Circle,Room 4207, Toronto, ON M5S 1A8, Canada

[3] Ctr Addict & Mental Hlth, Campbell Family Mental Hlth Res Inst, 475 Spadina Ave, Toronto, ON M5S 2S1, Canada

[4] Univ Toronto, Temerty Fac Med, Dept Med Biophys, Princess Margret Canc Res Tower,101 Coll St,Room 1, Toronto, ON M5G 1L7, Canada

[5] Ostfold Univ Coll, Dept Educ, B R A Veien 4, N-1757 Halden, Norway

[6] Western Univ, Dept Med Biophys, Med Sci Bldg,Room M407, London, ON N6A 5C1, Canada

[7] Western Univ, Robarts Res Inst, Ctr Funct & Metab Mapping, 1151 Richmond St, London, ON N6A 3K7, Canada

[8] Univ Western Ontario, Robarts Res Inst, 100 Perth Dr, London, ON N6A 5K8, Canada

[9] St Michaels Hosp, Data Sci & Adv Analyt DSAA, Unity Hlth Toronto, 36 Queen St East, Toronto, ON M5B 1W8, Canada

[10] Rotman Res Inst, Baycrest Ctr, 3560 Bathurst St, Toronto, ON M6A 2E1, Canada

[11] Univ Ottawa, Ottawa Hosp Res Inst, Dept Med, Div Neurol, 725 Parkdale Ave, Ottawa, ON K1Y 4E9, Canada

[12] Univ Toronto, St Michaels Hosp, Div Neurol, Stroke Outcomes & Decis Neurosci Res Unit, 30 Bond St, Toronto, ON M5B 1W8, Canada

[13] Thunder Bay Reg Hlth Res Inst, 1040 Oliver Rd, Thunder Bay, ON P7B 7A5, Canada

[14] Univ Hlth Network, Krembil Res Inst, 60 Leonard Ave, Toronto, ON M5T 0S8, Canada

[15] Univ Toronto, Temerty Fac Med, Div Neurol, Med Sci Bldg 1,Kings Coll Circle,Room 4207, Toronto, ON M5S 1A8, Canada

[16] Univ Hlth Network, Toronto Western Hosp, Edmond J Safra Program Parkinsons Dis, 399 Bathurst St, Toronto, ON M5T 2S8, Canada

[17] Keenan Res Ctr Biomed Sci, Unity Hlth, 209 Victoria St, Toronto, ON M5B 1T8, Canada

[18] Univ Ottawa, Bruyere Res Inst, 85 Primrose Ave, Ottawa, ON K1R 6M1, Canada

[19] Ctr Addict & Mental Hlth, Adult Neurodev & Geriatr Psychiat Div, 1001 Queen St West, Toronto, ON M6J 1H4, Canada

[20] Univ Toronto, Temerty Fac Med, Dept Psychiat, 250 Coll St, Toronto, ON M5T 1R8, Canada

[21] Univ Hlth Network Memory Clin, Toronto Western Hosp, 399 Bathurst St, Toronto, ON M5T 2S8, Canada

[22] Western Univ, Dept Clin Neurol Sci, 550 Wellington Rd, London, ON N6C 0A7, Canada

[23] Sunnybrook Res Inst, Harquail Ctr Neuromodulat, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada

[24] Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Med, Div Neurol, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada

[25] Univ Toronto, Rehabil Sci Inst, Temerty Fac Med, 1 Kings Coll Circle,Med Sci Bldg,Room 2109, Toronto, ON M5S 1A8, Canada

来源：

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES | 2023年 / 32卷 / 09期

关键词：

Perivascular spaces; Small vessel disease; Diabetes mellitus; Hypertension; Neurodegeneration; Cerebrovascular disease; WHITE-MATTER HYPERINTENSITIES; HYPERTENSION; PROGRESSION; DEMENTIA;

D O I：

10.1016/j.jstrokecerebrovasdis.2023.107273

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Type 2 diabetes mellitus (T2DM) and hypertension are risk factors for cerebral small vessel disease (SVD); however, few studies have characterised their relationships with MRI-visible perivascular spaces (PVS). MRI was used to quantify deep (d) and periventricular (p) white matter hyperintensities (WMH), lacunes, PVS in the white matter (wmPVS) or basal ganglia (bgPVS), and diffusion metrics in white matter. Patients with T2DM had greater wmPVS volume and there were greater wmPVS volumes in patients with T2DM and hypertension together. Counterfactual moderated mediation models found indirect effects of T2DM on volumes of other SVD and diffusion markers that were mediated by wmPVS: pWMH, dWMH, periventricular lacunes, and deep lacunes, and progression of deep lacunes over 1 year, in patients with hypertension, but not in patients without hypertension. Studying the regulation of cortical perivascular fluid dynamics may reveal mechanisms that mediate the impact of T2DM on cerebral small vessels.

引用

页数：8

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