5-HT and S100? values in evaluating severity of cognitive impairment after traumatic brain injury

Introduction: The aim of the study was to investigate the relationship between serum serotonin (5-HT) and central nervous sys-tem specific protein S100 beta application value in evaluating the severity of cognitive impairment after traumatic brain injury (TBI). Material and methods: 102 patients with TBI treated in Jilin Neuropsychiatric Hospital from June 2018 to October 2020 were selected. According to Montreal Cognitive Assessment (MoCA) scale, patients were tested for cognitive function from multiple levels, such as attention, executive function, memory, and language. Patients with cognitive impairment were included into study group (n = 64), and those without cognitive impairment were assigned to control group (n = 58). Serum 5-HT and S100 beta were compared between the two groups with beta level. Serum 5-HT and S100 beta were analyzed by receiver operating characteristic curve (ROC), beta application value judging cognitive impairment.Results: Serum 5-HT and S100 beta levels in the study group were significantly higher than those in the control group (p < 0.05). In serum 5-HT and S100 beta, there was a significant negative correlation with a MoCA score (r = -0.527, r = -0.436; p < 0.05, p < 0.05). Combined detection of serum 5-HT and S100 beta's area under ROC curve (AUC) was 0.810 (95% CI: 0.742-0.936, p < 0.05), sensitivity was 0.842, and specificity was 0.813.Conclusions: Serum 5-HT and S100 beta levels are closely related to the cognitive function of TBI patients. Combined detection is helpful to improve the accuracy of predicting cognitive impairment.