Synchronous gastric MALT lymphoma and gastric adenocarcinoma of fundic gland type arising from a hamartomatous inverted polyp in a Helicobacter pylori naive patient

被引：1

作者：

Miyamoto, Ryo ^{[1
]}

Takigawa, Hidehiko ^{[1
]}

Kotachi, Takahiro ^{[1
]}

Kadota, Hiroki ^{[1
]}

Yuge, Ryo ^{[1
]}

Hayashi, Ryohei ^{[1
]}

Urabe, Yuji ^{[3
]}

Ishikawa, Akira ^{[4
]}

Sentani, Kazuhiro ^{[4
]}

Oka, Shiro ^{[2
]}

机构：

[1] Hiroshima Univ Hosp, Dept Endoscopy, 1-2-3 Kasumi,Minami Ku, Hiroshima, Japan

[2] Hiroshima Univ Hosp, Dept Gastroenterol, Hiroshima 7348553, Japan

[3] Hiroshima Univ Hosp, Dept Gastrointestinal Endoscopy & Med, Hiroshima, Japan

[4] Hiroshima Univ Hosp, Dept Mol Pathol, Hiroshima, Japan

来源：

CLINICAL JOURNAL OF GASTROENTEROLOGY | 2023年 / 16卷 / 04期

关键词：

Gastric cancer; MALT lymphoma; Gastric adenocarcinoma; Hp infection; MALIGNANT-LYMPHOMA; TISSUE; INFECTION; STOMACH; CANCER; ERADICATION; COLLISION;

D O I：

10.1007/s12328-023-01808-8

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We present a rare case that showed the coexistence of gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma in Helicobacter pylori-naive stomach. A 72-year-old man was followed up after surgery for epithelial carcinoma of the glottis at the Department of Otolaryngology. He underwent an upper gastrointestinal endoscopy for an abnormal PET-CT accumulation, which revealed gastric adenocarcinoma of fundic gland type in the gastric fundus and MALT lymphoma in the upper gastric body. Hence, we performed an endoscopic submucosal dissection for gastric cancer and diagnosed gastric adenocarcinoma of fundic gland type derived from a hamartomatous-inverted polyp. Subsequently, Gastric MALT lymphoma was treated with radiation therapy because the API2-MALT1 gene was positive and the Helicobacter pylori infection was negative. A complete response was observed. Even in Hp-naive stomachs, cases such as the present case are complicated by special types of gastric cancer and MALT lymphoma, and endoscopic examination should be performed with these diseases in mind.

引用

页码：521 / 526

页数：6

共 31 条

[1] Collision of EBV-associated gastric carcinoma and primary gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue in the remnant stomach [J].

Akiba, Jun ;

Nakane, Tomoyuki ;

Arakawa, Fumiko ;

Ohshima, Koichi ;

Yano, Hirohisa .

PATHOLOGY INTERNATIONAL, 2010, 60 (02) :102-106

[2] Second primary malignancies in patients treated for gastric mucosa-associated lymphoid tissue lymphoma [J].

Amiot, Aurelien ;

Jooste, Valerie ;

Gagniere, Charlotte ;

Levy, Michael ;

Copie-Bergman, Christiane ;

Dupuis, Jehan ;

Le Baleur, Yann ;

Belhadj, Karim ;

Sobhani, Iradj ;

Haioun, Corinne ;

Bouvier, Anne-Marie ;

Delchier, Jean-Charles .

LEUKEMIA & LYMPHOMA, 2017, 58 (09) :2057-2064

[3] Helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphomas: A review [J].

Asano, Naoki ;

Iijima, Katsunori ;

Koike, Tomoyuki ;

Imatani, Akira ;

Shimosegawa, Tooru .

WORLD JOURNAL OF GASTROENTEROLOGY, 2015, 21 (26) :8014-8020

[4] New Insights in Histogenetic Pathways of Gastric Cancer [J].

Gurzu, Simona ;

Sugimura, Haruhiko ;

Orlowska, Janina ;

Szentirmay, Zoltan ;

Jung, Ioan .

MEDICINE, 2015, 94 (42) :e1810

[5] Endoscopic Submucosal Dissection of an Inverted Pyloric Gland Adenoma Using Dental Floss and Clip Traction [J].

Ha Kim, Gwang ;

Lee, Moon Won ;

Lee, Bong Eun ;

Park, Do Youn .

CLINICAL ENDOSCOPY, 2021, 54 (06) :935-936

[6] A case of Helicobacter pylori infection complicated with gastric cancer, gastric mucosa-associated lymphoid tissue lymphoma, and idiopathic thrombocytopenic purpura successfully treated with laparoscopy-assisted total gastrectomy and splenectomy [J].

Hamabe, A. ;

Omori, T. ;

Oyama, T. ;

Akamatsu, H. ;

Yoshidome, K. ;

Tori, M. ;

Ueshima, S. ;

Tsujimoto, M. ;

Nishida, T. .

ASIAN JOURNAL OF ENDOSCOPIC SURGERY, 2011, 4 (01) :32-35

[7] Characteristic endoscopic findings of gastric adenocarcinoma of fundic-gland mucosa type [J].

Imamura, Kentaro ;

Yao, Kenshi ;

Nimura, Satoshi ;

Tanabe, Hiroshi ;

Kanemitsu, Takao ;

Miyaoka, Masaki ;

Ono, Yoichiro ;

Ueki, Toshiharu ;

Iwashita, Akinori .

GASTRIC CANCER, 2021, 24 (06) :1307-1319

[8]

ISAACSON P, 1983, CANCER-AM CANCER SOC, V52, P1410, DOI 10.1002/1097-0142(19831015)52:8<1410::AID-CNCR2820520813>3.0.CO

[9]

2-3

[10] Clinicopathological studies on coexisting gastric malignant lymphoma and gastric adenocarcinoma: Report of four cases and review of the Japanese literature [J].

Ishihama, T ;

Kondo, H ;

Saito, D ;

Yamaguchi, H ;

Shirao, K ;

Yokota, T ;

Hosokawa, K ;

Ono, H ;

Iwabuchi, M ;

Gotoda, T ;

Matsuno, Y ;

Boku, N ;

Ohtsu, A ;

Yoshida, S .

JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 1997, 27 (02) :101-106

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