Patient-derived organoids: a promising tool for breast cancer research

被引：4

作者：

Shi, Yixin ^{[1
,2
]}

Guan, Zhanwen ^{[3
]}

Cai, Gengxi ^{[4
]}

Nie, Yichu ^{[3
]}

Zhang, Chuling ^{[3
]}

Luo, Wei ^{[3
]}

Liu, Jia ^{[1
,2
]}

机构：

[1] Dalian Med Univ, Liaoning Lab Canc Genom, Dalian, Peoples R China

[2] Dalian Med Univ, Coll Basic Med Sci, Dept Cell Biol, Dalian, Peoples R China

[3] First Peoples Hosp Foshan, Translat Med Res Inst, Foshan, Peoples R China

[4] First Peoples Hosp Foshan, Dept Breast Surg, Foshan, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2024年 / 14卷

关键词：

breast cancer; patient-derived organoids; tumor microenvironment; drug screening; individualized therapy; MAMMARY EPITHELIAL-CELLS; IN-VITRO; STEM-CELLS; EXTRACELLULAR-MATRIX; TERM CULTURE; TUMOR; DIFFERENTIATION; MODEL; HETEROGENEITY; PROGRESSION;

D O I：

10.3389/fonc.2024.1350935

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer (BC) is the most prevalent malignancy among women worldwide. Traditional research models such as primary cancer cell and patient-derived tumor xenografts (PDTXs) have limitations. Cancer cells lack a tumor microenvironment (TME) and genetic diversity, whereas PDTXs are expensive and have a time-consuming preparation protocol. Therefore, alternative research models are warranted. Patient-derived organoids (PDOs) are a promising in vitro model. They mimic the TME, gene expression, and cell types of original cancer tissues. PDOs have been successfully developed from various cancers, including BC. In this review, we focused on the value and limitations of PDOs in BC research, including their characteristics and potential in drug development, personalized therapy, immunotherapy, and the application prospects of PDOs in drug testing and prognosis.

引用

页数：11

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