Patient-derived organoids: a promising tool for breast cancer research

被引：4

作者：

Shi, Yixin ^{[1
,2
]}

Guan, Zhanwen ^{[3
]}

Cai, Gengxi ^{[4
]}

Nie, Yichu ^{[3
]}

Zhang, Chuling ^{[3
]}

Luo, Wei ^{[3
]}

Liu, Jia ^{[1
,2
]}

机构：

[1] Dalian Med Univ, Liaoning Lab Canc Genom, Dalian, Peoples R China

[2] Dalian Med Univ, Coll Basic Med Sci, Dept Cell Biol, Dalian, Peoples R China

[3] First Peoples Hosp Foshan, Translat Med Res Inst, Foshan, Peoples R China

[4] First Peoples Hosp Foshan, Dept Breast Surg, Foshan, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2024年 / 14卷

关键词：

breast cancer; patient-derived organoids; tumor microenvironment; drug screening; individualized therapy; MAMMARY EPITHELIAL-CELLS; IN-VITRO; STEM-CELLS; EXTRACELLULAR-MATRIX; TERM CULTURE; TUMOR; DIFFERENTIATION; MODEL; HETEROGENEITY; PROGRESSION;

D O I：

10.3389/fonc.2024.1350935

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer (BC) is the most prevalent malignancy among women worldwide. Traditional research models such as primary cancer cell and patient-derived tumor xenografts (PDTXs) have limitations. Cancer cells lack a tumor microenvironment (TME) and genetic diversity, whereas PDTXs are expensive and have a time-consuming preparation protocol. Therefore, alternative research models are warranted. Patient-derived organoids (PDOs) are a promising in vitro model. They mimic the TME, gene expression, and cell types of original cancer tissues. PDOs have been successfully developed from various cancers, including BC. In this review, we focused on the value and limitations of PDOs in BC research, including their characteristics and potential in drug development, personalized therapy, immunotherapy, and the application prospects of PDOs in drug testing and prognosis.

引用

页数：11

共 82 条

[1] Toward understanding and exploiting tumor heterogeneity [J].

Alizadeh, Ash A. ;

Aranda, Victoria ;

Bardelli, Alberto ;

Blanpain, Cedric ;

Bock, Christoph ;

Borowski, Christine ;

Caldas, Carlos ;

Califano, Andrea ;

Doherty, Michael ;

Elsner, Markus ;

Esteller, Manel ;

Fitzgerald, Rebecca ;

Korbel, Jan O. ;

Lichter, Peter ;

Mason, Christopher E. ;

Navin, Nicholas ;

Pe'er, Dana ;

Polyak, Kornelia ;

Roberts, Charles W. M. ;

Siu, Lillian ;

Snyder, Alexandra ;

Stower, Hannah ;

Swanton, Charles ;

Verhaak, Roel G. W. ;

Zenklusen, Jean C. ;

Zuber, Johannes ;

Zucman-Rossi, Jessica .

NATURE MEDICINE, 2015, 21 (08) :846-853

[2] Engineering cancer microenvironments for in vitro 3-D tumor models [J].

Asghar, Waseem ;

El Assal, Rami ;

Shafiee, Hadi ;

Pitteri, Sharon ;

Paulmurugan, Ramasamy ;

Demirci, Utkan .

MATERIALS TODAY, 2015, 18 (10) :539-553

[3] In Vitro Expansion of Human Gastric Epithelial Stem Cells and Their Responses to Bacterial Infection [J].

Bartfeld, Sina ;

Bayram, Tulay ;

van de Wetering, Marc ;

Huch, Meritxell ;

Begthel, Harry ;

Kujala, Pekka ;

Vries, Robert ;

Peters, Peter J. ;

Clevers, Hans .

GASTROENTEROLOGY, 2015, 148 (01) :126-U554

[4] Genetic and transcriptional evolution alters cancer cell line drug response [J].

Ben-David, Uri ;

Siranosian, Benjamin ;

Ha, Gavin ;

Tang, Helen ;

Oren, Yaara ;

Hinohara, Kunihiko ;

Strathdee, Craig A. ;

Dempster, Joshua ;

Lyons, Nicholas J. ;

Burns, Robert ;

Nag, Anwesha ;

Kugener, Guillaume ;

Cimini, Beth ;

Tsvetkov, Peter ;

Maruvka, Yosef E. ;

O'Rourke, Ryan ;

Garrity, Anthony ;

Tubelli, Andrew A. ;

Bandopadhayay, Pratiti ;

Tsherniak, Aviad ;

Vazquez, Francisca ;

Wong, Bang ;

Birger, Chet ;

Ghandi, Mahmoud ;

Thorner, Aaron R. ;

Bittker, Joshua A. ;

Meyerson, Matthew ;

Getz, Gad ;

Beroukhim, Rameen ;

Golub, Todd R. .

NATURE, 2018, 560 (7718) :325-+

[5] Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics [J].

Bhatia, Sonam ;

Kramer, Melissa ;

Russo, Suzanne ;

Naik, Payal ;

Arun, Gayatri ;

Brophy, Kyle ;

Andrews, Peter ;

Fan, Cheng ;

Perou, Charles M. ;

Preall, Jonathan ;

Ha, Taehoon ;

Plenker, Dennis ;

Tuveson, David A. ;

Rishi, Arvind ;

Wilkinson, John E. ;

McCombie, W. Richard ;

Kostroff, Karen ;

Spector, David L. .

CANCER RESEARCH, 2022, 82 (07) :1174-1192

[6] HOW DOES THE EXTRACELLULAR-MATRIX DIRECT GENE-EXPRESSION [J].

BISSELL, MJ ;

HALL, HG ;

PARRY, G .

JOURNAL OF THEORETICAL BIOLOGY, 1982, 99 (01) :31-68

[7] Identification of shared tumor epitopes from endogenous retroviruses inducing high-avidity cytotoxic T cells for cancer immunotherapy [J].

Bonaventura, Paola ;

Alcazer, Vincent ;

Mutez, Virginie ;

Tonon, Laurie ;

Martin, Juliette ;

Chuvin, Nicolas ;

Michel, Emilie ;

Boulos, Rasha E. ;

Estornes, Yann ;

Valladeau-Guilemond, Jenny ;

Viari, Alain ;

Wang, Qing ;

Caux, Christophe ;

Depil, Stephane .

SCIENCE ADVANCES, 2022, 8 (04)

[8] A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds [J].

Bruna, Alejandra ;

Rueda, Oscar M. ;

Greenwood, Wendy ;

Batra, Ankita Sati ;

Callari, Maurizio ;

Batra, Rajbir Nath ;

Pogrebniak, Katherine ;

Sandoval, Jose ;

Cassidy, John W. ;

Tufegdzic-Vidakovic, Ana ;

Sammut, Stephen-John ;

Jones, Linda ;

Provenzano, Elena ;

Baird, Richard ;

Eirew, Peter ;

Hadfield, James ;

Eldridge, Matthew ;

McLaren-Douglas, Anne ;

Barthorpe, Andrew ;

Lightfoot, Howard ;

O'Connor, Mark J. ;

Gray, Joe ;

Cortes, Javier ;

Baselga, Jose ;

Marangoni, Elisabetta ;

Welm, Alana L. ;

Aparicio, Samuel ;

Serra, Violeta ;

Garnett, Mathew J. ;

Caldas, Carlos .

CELL, 2016, 167 (01) :260-+

[9] Advances in the preclinical testing of cancer therapeutic hypotheses [J].

Caponigro, Giordano ;

Sellers, William R. .

NATURE REVIEWS DRUG DISCOVERY, 2011, 10 (03) :179-187

[10] Patient-Derived Organoids Can Guide Personalized-Therapies for Patients with Advanced Breast Cancer [J].

Chen, Ping ;

Zhang, Xu ;

Ding, Renbo ;

Yang, Linglin ;

Lyu, Xueying ;

Zeng, Jianming ;

Lei, Josh Haipeng ;

Wang, Lijian ;

Bi, Jiong ;

Shao, Nan ;

Shu, Ditian ;

Wu, Bin ;

Wu, Jingbo ;

Yang, Zhihui ;

Wang, Haiyan ;

Wang, Biqiong ;

Xiong, Kang ;

Lu, Yun ;

Fu, Shaozhi ;

Choi, Tak Kan ;

Lon, Ng Wai ;

Zhang, Aiping ;

Tang, Dongyang ;

Quan, Yingyao ;

Meng, Ya ;

Miao, Kai ;

Sun, Heng ;

Zhao, Ming ;

Bao, Jiaolin ;

Zhang, Lei ;

Xu, Xiaoling ;

Shi, Yanxia ;

Lin, Ying ;

Deng, Chuxia .

ADVANCED SCIENCE, 2021, 8 (22)

← 1 2 3 4 5 6 7 8 9 →