Metabolic Profiling to Assess Response to Targeted and Immune Therapy in Melanoma

被引：2
作者：
Farah, Chantale [1 ]
Mignion, Lionel [2 ]
Jordan, Benedicte F. [1 ,2 ]
机构：
[1] Univ Catholique Louvain UCLouvain, Louvain Drug Res Inst, Biomed Magnet Resonance Res Grp, B-1200 Brussels, Belgium
[2] Univ Catholique Louvain UCLouvain, Louvain Drug Res Inst LDRI, Nucl & Electron Spin Technol NEST Platform, B-1200 Brussels, Belgium
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 03期
关键词：
melanoma; metabolic imaging; response to treatment; BRAF-targeted therapy; immune checkpoint inhibitors; BRAF-MUTANT MELANOMA; MEK INHIBITION; TUMOR MICROENVIRONMENT; ACQUIRED-RESISTANCE; GLUCOSE-METABOLISM; ANTITUMOR-ACTIVITY; CLINICAL-RESPONSE; IMPROVED SURVIVAL; CELL-ACTIVATION; F-18-FDG PET/CT;
D O I：
10.3390/ijms25031725
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
There is currently no consensus to determine which advanced melanoma patients will benefit from targeted therapy, immunotherapy, or a combination of both, highlighting the critical need to identify early-response biomarkers to advanced melanoma therapy. The goal of this review is to provide scientific rationale to highlight the potential role of metabolic imaging to assess response to targeted and/or immune therapy in melanoma cancer. For that purpose, a brief overview of current melanoma treatments is provided. Then, current knowledge with respect to melanoma metabolism is described with an emphasis on major crosstalks between melanoma cell metabolism and signaling pathways involved in BRAF-targeted therapy as well as in immune checkpoint inhibition therapies. Finally, preclinical and clinical studies using metabolic imaging and/or profiling to assess response to melanoma treatment are summarized with a particular focus on PET (Positron Emission Tomography) imaging and 13C-MRS (Magnetic Resonance Spectroscopy) methods.
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页数：21
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