Clinical considerations and pathophysiological associations among obesity, weight loss, heart failure, and hypertension

被引：1

作者：

Barillas-Lara, Maria Irene ^{[1
]}

Faaborg-Andersen, Christian C. C. ^{[2
]}

Quintana, Raymundo A. A. ^{[3
]}

Loro-Ferrer, Juan Francisco ^{[4
]}

Mandras, Stacy A. A. ^{[5
]}

daSilva-deAbreu, Adrian ^{[4
,6
,7
]}

机构：

[1] Montefiore Dept Cardiovasc Dis, Bronx, NY USA

[2] Massachusetts Gen Hosp, Dept Internal Med, Boston, MA USA

[3] Univ Colorado, Div Cardiol, Cardiovasc Imaging Sect, Aurora, CO USA

[4] Univ Las Palmas Gran Canaria, Doctoral Sch, Las Palmas Gran Canaria, Spain

[5] Orlando AdventHlth, Transplant Inst, Orlando, FL USA

[6] Mayo Clin, Dept Cardiovasc Med, Rochester, MN 55905 USA

[7] Mayo Clin, 200 1st St SW, Rochester, MN 55905 USA

来源：

CURRENT OPINION IN CARDIOLOGY | 2023年 / 38卷 / 05期

关键词：

bariatric surgery; heart failure; hypertension; obesity; weight loss; BODY-MASS INDEX; BARIATRIC SURGERY; BLOOD-PRESSURE; CARDIOVASCULAR RISK; AMERICAN SOCIETY; SLEEP-APNEA; TERM; OVERWEIGHT; MORTALITY; IMPROVEMENT;

D O I：

10.1097/HCO.0000000000001069

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of reviewTo describe the relationship between three pandemics: hypertension, obesity, and heart failure. From pathophysiology to treatment, understanding how these disease entities are linked can lead to breakthroughs in their prevention and treatment. The relevance of this review lies in its discussion of novel pharmacological and surgical treatment strategies for obesity and hypertension, and their role in the prevention and treatment of heart failure.Recent findingsNovel medications such as GLP-1 agonists have demonstrated sustained weight loss in patients with obesity, and concurrent improvements in their cardiometabolic profile, and possibly also reductions in hypertension-related comorbidities including heart failure. Surgical therapies including laparoscopic bariatric surgery represent an important treatment strategy in obese patients, and recent studies describe their use even in patients with advanced heart failure, including those with ventricular assist devices.These developments have deep implications on our efforts to understand, mitigate, and ultimately prevent the three pandemics, and offer promising improvements to quality of life, survival, and the cost burden of these diseases.

引用

页码：447 / 455

页数：9

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