A review on selected herbal plants as alternative anti-diabetes drugs: chemical compositions, mechanisms of action, and clinical study

被引：6

作者：

Ahda, Mustofa ^{[1
,3
,4
]}

Jaswir, Irwandi ^{[2
,5
]}

Khatib, Alfi ^{[4
]}

Ahmed, Qamar Uddin ^{[4
]}

Mahfudh, Nurkhasanah ^{[1
]}

Ardini, Yunita Dewi ^{[6
]}

机构：

[1] Univ Ahmad Dahlan, Fac Pharm, Dept Pharmaceut Chem, Yogyakarta, Indonesia

[2] Univ Ahmad Dahlan, Fac Pharm, Dept Pharmaceut Technol, Yogyakarta, Indonesia

[3] Univ Ahmad Dahlan, Ahmad Dahlan Halal Ctr, Yogyakarta, Indonesia

[4] Int Islamic Univ Malaysia, Dept Pharmaceut Chem, Kuantan, Malaysia

[5] Int Islamic Univ Malaysia, INHART, Kuala Lumpur, Malaysia

[6] Int Islamic Univ Malaysia, Paediat Dent & Dent Publ Hlth Dept, Kulliyyah Dent, Kuantan, Malaysia

来源：

INTERNATIONAL JOURNAL OF FOOD PROPERTIES | 2023年 / 26卷 / 01期

关键词：

Anti-diabetes; herbal medicines; mechanisms of action; clinical study; TRADITIONAL CHINESE MEDICINE; MORINGA-OLEIFERA; TYPE-2; TRIAL;

D O I：

10.1080/10942912.2023.2215475

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Herbal utilization, as an antidiabetes agent, is an interesting topic to find acceptable herbal drugs to decrease blood glucose levels. The aim of this review is to evaluate the potency of selected herbal medicines to reduce blood glucose levels and to identify the chemical compounds responsible for reducing glucose. The mechanisms of action of different herbal medicines used might be also different. The reduction of blood glucose levels by Aloe vera, Andrographis paniculata, and Trigonella foenum-graecum through minimum 3 mechanisms of action, such as increased GLP-1 secretion and inhibited amylase, glucosidase, and SGLT 2. While Andrographis paniculata has more than 4 mechanisms of action, such as increasing GLP secretion, activating PPAR gamma-receptor, and also inhibiting amylase, glucosidase, and SGLT 2 but it did not inhibit DPP 4 in diabetic patients.

引用

页码：1414 / 1425

页数：12

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